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    Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 [ Mus musculus (house mouse) ]

    Gene ID: 76252, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atp6v0e2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit E2provided by MGI
    Primary source
    MGI:MGI:1923502
    See related
    Ensembl:ENSMUSG00000039347 AllianceGenome:MGI:1923502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NM9.2; 0610006O14Rik
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in synaptic vesicle membrane. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; and tongue. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 116.9), cerebellum adult (RPKM 109.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Atp6v0e2 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48514503..48518735)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48537569..48541801)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 862, pseudogene Neighboring gene PEST proteolytic signal containing nuclear protein pseudogene Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene leucine rich repeat containing 61 Neighboring gene retinoic acid receptor responder (tazarotene induced) 2 Neighboring gene predicted gene 5111

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General protein information

    Preferred Names
    V-type proton ATPase subunit e 2
    Names
    ATPase, H+ transporting, lysosomal, V0 subunit E
    V-ATPase subunit e 2
    vacuolar proton pump subunit e 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347164.1NP_001334093.1  V-type proton ATPase subunit e 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS85039.1
      UniProtKB/TrEMBL
      A0A0N4SVQ2
      Related
      ENSMUSP00000145198.2, ENSMUST00000203011.2
    2. NM_133764.3NP_598525.1  V-type proton ATPase subunit e 2 isoform 1

      See identical proteins and their annotated locations for NP_598525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AC154013, AI839056, AK077313, BY296901
      Consensus CDS
      CCDS20103.1
      UniProtKB/Swiss-Prot
      Q91XE7
      Related
      ENSMUSP00000044110.6, ENSMUST00000040361.8
      Conserved Domains (1) summary
      pfam05493
      Location:967
      ATP_synt_H; ATP synthase subunit H

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48514503..48518735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)