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    Tyro3 TYRO3 protein tyrosine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 22174, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tyro3provided by MGI
    Official Full Name
    TYRO3 protein tyrosine kinase 3provided by MGI
    Primary source
    MGI:MGI:104294
    See related
    Ensembl:ENSMUSG00000027298 AllianceGenome:MGI:104294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brt; Dtk; Rse; Sky; Tif; Etk-2; TK19-2; tk19-1; etk2/tyro3
    Summary
    Predicted to enable phosphatidylinositol 3-kinase binding activity; transmembrane receptor protein tyrosine kinase activity; and virus receptor activity. Involved in several processes, including platelet aggregation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of defense response. Acts upstream of or within several processes, including nervous system development; substrate adhesion-dependent cell spreading; and vagina development. Predicted to be located in cell surface; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; limb; and sensory organ. Used to study autoimmune disease. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 29.2), cerebellum adult (RPKM 26.7) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tyro3 in Genome Data Viewer
    Location:
    2 E5; 2 59.97 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119628123..119648585)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119797740..119818104)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05495 Neighboring gene RNA polymerase II associated protein 1 Neighboring gene predicted gene, 23814 Neighboring gene STARR-seq mESC enhancer starr_05497 Neighboring gene STARR-seq mESC enhancer starr_05498 Neighboring gene STARR-seq mESC enhancer starr_05499 Neighboring gene fatty acid binding protein 5, epidermal pseudogene Neighboring gene MAX gene associated Neighboring gene STARR-positive B cell enhancer ABC_E1252 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene microRNA 7665

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol 3-kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic cell clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in apoptotic cell clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within forebrain cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of lymphocyte activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within natural killer cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of innate immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of lymphocyte activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of toll-like receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovulation cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of viral life cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within secretion by cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vagina development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase receptor TYRO3
    Names
    receptor tyrosine kinase
    tyrosine-protein kinase DTK
    tyrosine-protein kinase RSE
    tyrosine-protein kinase TIF
    NP_001277729.1
    NP_001408100.1
    NP_062265.2
    XP_006499223.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290800.2NP_001277729.1  tyrosine-protein kinase receptor TYRO3 isoform B

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternative 5' exon structure, and it thus differs in its 5' UTR and initiates translation from an alternative start codon, compared to variant 1. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.
      Source sequence(s)
      AL844896
      Consensus CDS
      CCDS71119.1
      UniProtKB/TrEMBL
      Q62121
      Related
      ENSMUSP00000106410.2, ENSMUST00000110783.8
      Conserved Domains (7) summary
      smart00408
      Location:42107
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:35121
      IG_like; Immunoglobulin like
      cd00063
      Location:211303
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:494777
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:311392
      fn3; Fibronectin type III domain
      pfam07714
      Location:504772
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:127205
      Ig; Immunoglobulin domain
    2. NM_001421171.1NP_001408100.1  tyrosine-protein kinase receptor TYRO3 isoform C

      Status: VALIDATED

      Source sequence(s)
      AL844896
      UniProtKB/TrEMBL
      Q62121
    3. NM_019392.3NP_062265.2  tyrosine-protein kinase receptor TYRO3 isoform A precursor

      See identical proteins and their annotated locations for NP_062265.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (A).
      Source sequence(s)
      AL844896
      Consensus CDS
      CCDS16611.1
      UniProtKB/Swiss-Prot
      O09070, O09080, P55144, P70285, Q60752, Q62482, Q62483, Q62484, Q6NZM6, Q78E85, Q78E87
      UniProtKB/TrEMBL
      Q62121
      Related
      ENSMUSP00000028763.10, ENSMUST00000028763.10
      Conserved Domains (7) summary
      smart00408
      Location:46111
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:39125
      IG_like; Immunoglobulin like
      cd00063
      Location:215307
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:498781
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:315396
      fn3; Fibronectin type III domain
      pfam07714
      Location:508776
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:131209
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119628123..119648585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499160.1XP_006499223.1  tyrosine-protein kinase receptor TYRO3 isoform X1

      UniProtKB/TrEMBL
      Q62121
      Conserved Domains (5) summary
      smart00408
      Location:1176
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:180272
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05074
      Location:463746
      PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
      pfam00041
      Location:280360
      fn3; Fibronectin type III domain
      cl11960
      Location:96174
      Ig; Immunoglobulin domain