U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cacnb1 calcium channel, voltage-dependent, beta 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 12295, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cacnb1provided by MGI
    Official Full Name
    calcium channel, voltage-dependent, beta 1 subunitprovided by MGI
    Primary source
    MGI:MGI:102522
    See related
    Ensembl:ENSMUSG00000020882 AllianceGenome:MGI:102522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAB1; Cchb1; Cchlb1
    Summary
    Enables high voltage-gated calcium channel activity. Acts upstream of or within calcium ion transport and protein targeting to membrane. Located in T-tubule and sarcoplasmic reticulum. Part of voltage-gated calcium channel complex. Is active in presynapse. Is expressed in several structures, including heart; lower leg rest of mesenchyme; nervous system; skeletal musculature; and urinary system. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 23.5), cortex adult (RPKM 19.4) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cacnb1 in Genome Data Viewer
    Location:
    11 D; 11 61.5 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97892339..97913860, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98001508..98023034, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5273 Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene ADP-ribosylation factor-like 5C Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-positive B cell enhancer ABC_E9372 Neighboring gene STARR-seq mESC enhancer starr_30655 Neighboring gene STARR-seq mESC enhancer starr_30656 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97944979-97945162 Neighboring gene F-box and leucine-rich repeat protein 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables high voltage-gated calcium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of L-type voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in T-tubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-1
    Names
    calcium channel voltage-dependent subunit beta 1
    voltage-dependent calcium channel beta1 subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159319.3NP_001152791.1  voltage-dependent L-type calcium channel subunit beta-1 isoform C

      See identical proteins and their annotated locations for NP_001152791.1

      Status: VALIDATED

      Source sequence(s)
      AL591209
      Consensus CDS
      CCDS48899.1
      UniProtKB/TrEMBL
      Q6DD95
      Related
      ENSMUSP00000103187.2, ENSMUST00000107562.2
      Conserved Domains (3) summary
      cd12041
      Location:99166
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      pfam00625
      Location:228408
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    2. NM_001159320.2NP_001152792.1  voltage-dependent L-type calcium channel subunit beta-1 isoform D

      See identical proteins and their annotated locations for NP_001152792.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 5. The resulting isoform (D) has shorter and distinct N- and C-termini compared to isoform E.
      Source sequence(s)
      AL591209
      Consensus CDS
      CCDS48898.1
      UniProtKB/TrEMBL
      A2A542, Q3U2N3
      Related
      ENSMUSP00000103186.3, ENSMUST00000107561.9
      Conserved Domains (3) summary
      cd12041
      Location:52119
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      pfam12052
      Location:1152
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:226406
      Guanylate_kin; Guanylate kinase
    3. NM_001282977.2NP_001269906.1  voltage-dependent L-type calcium channel subunit beta-1 isoform E

      Status: VALIDATED

      Source sequence(s)
      AL591209
      UniProtKB/TrEMBL
      I2FKE4
      Conserved Domains (4) summary
      smart00072
      Location:283454
      GuKc; Guanylate kinase homologues
      pfam00625
      Location:273453
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17036
      Location:99166
      SH3; Src Homology 3 domain superfamily
    4. NM_001282978.2NP_001269907.1  voltage-dependent L-type calcium channel subunit beta-1 isoform F

      Status: VALIDATED

      Source sequence(s)
      AL591209
      UniProtKB/TrEMBL
      Q6DD95
      Conserved Domains (3) summary
      cd12041
      Location:99166
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:220400
      Guanylate_kin; Guanylate kinase
    5. NM_001430870.1NP_001417799.1  voltage-dependent L-type calcium channel subunit beta-1 isoform G

      Status: VALIDATED

      Source sequence(s)
      AL591209
      UniProtKB/Swiss-Prot
      A2A544, O88517, Q7TPF2, Q8R3Z5, Q8R3Z6, Q9EPT9
    6. NM_001430871.1NP_001417800.1  voltage-dependent L-type calcium channel subunit beta-1 isoform H

      Status: VALIDATED

      Source sequence(s)
      AL591209
    7. NM_031173.5NP_112450.1  voltage-dependent L-type calcium channel subunit beta-1 isoform A

      See identical proteins and their annotated locations for NP_112450.1

      Status: VALIDATED

      Source sequence(s)
      AL591209
      Consensus CDS
      CCDS25336.1
      UniProtKB/TrEMBL
      A2A545, Q3U2N3
      Related
      ENSMUSP00000090412.5, ENSMUST00000092736.11
      Conserved Domains (4) summary
      cd12041
      Location:99166
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      smart00072
      Location:283454
      GuKc; Guanylate kinase homologues
      pfam00625
      Location:273453
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    8. NM_145121.4NP_660099.2  voltage-dependent L-type calcium channel subunit beta-1 isoform B

      Status: VALIDATED

      Source sequence(s)
      AL591209
      Consensus CDS
      CCDS25335.1
      UniProtKB/Swiss-Prot
      A2A544, O88517, Q7TPF2, Q8R3Z5, Q8R3Z6, Q9EPT9
      UniProtKB/TrEMBL
      A2A543
      Related
      ENSMUSP00000017552.7, ENSMUST00000017552.13
      Conserved Domains (3) summary
      pfam00625
      Location:228408
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:5899
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17036
      Location:99166
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97892339..97913860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245499.1XP_030101359.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X4

      Conserved Domains (1) summary
      pfam00625
      Location:1180
      Guanylate_kin; Guanylate kinase
    2. XM_036156255.1XP_036012148.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      I2FKE4
      Conserved Domains (3) summary
      cd12041
      Location:52119
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      pfam00625
      Location:226406
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:1152
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    3. XM_030245500.2XP_030101360.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X4

      Conserved Domains (1) summary
      pfam00625
      Location:1180
      Guanylate_kin; Guanylate kinase
    4. XM_006532092.4XP_006532155.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X2

      Conserved Domains (3) summary
      cd12041
      Location:111178
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      pfam00625
      Location:240420
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:70111
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    5. XM_006532091.4XP_006532154.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      I2FKE4
      Conserved Domains (3) summary
      cd12041
      Location:111178
      SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
      pfam00625
      Location:285465
      Guanylate_kin; Guanylate kinase
      pfam12052
      Location:70111
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal