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    Fbxo47 F-box protein 47 [ Mus musculus (house mouse) ]

    Gene ID: 72973, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxo47provided by MGI
    Official Full Name
    F-box protein 47provided by MGI
    Primary source
    MGI:MGI:1920223
    See related
    Ensembl:ENSMUSG00000070336 AllianceGenome:MGI:1920223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1562; 2900052P03Rik
    Summary
    Orthologous to human FBXO47 (F-box protein 47). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 1.7), cortex adult (RPKM 0.2) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxo47 in Genome Data Viewer
    Location:
    11 D; 11 61.14 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97741137..97775240, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97850311..97884386, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7052 Neighboring gene nuclear encoded tRNA cysteine 51 (anticodon GCA) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97669517-97669700 Neighboring gene LIM and SH3 protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97686746-97686855 Neighboring gene RIKEN cDNA B230217C12 gene Neighboring gene STARR-seq mESC enhancer starr_30642 Neighboring gene STARR-seq mESC enhancer starr_30643 Neighboring gene STARR-positive B cell enhancer ABC_E3011 Neighboring gene STARR-seq mESC enhancer starr_30644 Neighboring gene STARR-seq mESC enhancer starr_30646 Neighboring gene plexin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_30648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97839153-97839454 Neighboring gene predicted gene 11633 Neighboring gene STARR-positive B cell enhancer ABC_E7053 Neighboring gene STARR-positive B cell enhancer ABC_E3012 Neighboring gene nuclear encoded tRNA cysteine 55 (anticodon GCA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis. Chen Y, et al. Cell Res, 2018 Sep. PMID 30061742, Free PMC Article
    2. FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis. Hua R, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31724724, Free PMC Article
    3. FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. Tanno N, et al. iScience, 2022 Apr 15. PMID 35310947, Free PMC Article
    4. Effects of glucokinase haploinsufficiency on the pancreatic β-cell mass and function of long-term high-fat, high-sucrose diet-fed mice. Shigesawa I, et al. J Diabetes Investig, 2024 Dec. PMID 39305123, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC118329

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081435.2 → NP_001074904.1  F-box only protein 47 isoform 1

      See identical proteins and their annotated locations for NP_001074904.1

      Status: VALIDATED

      Source sequence(s)
      AL596446
      Consensus CDS
      CCDS36299.1
      UniProtKB/Swiss-Prot
      A2A6H3, B2RY07
      Related
      ENSMUSP00000091471.4, ENSMUST00000093939.4
      Conserved Domains (1) summary
      pfam00646
      Location:47 → 78
      F-box; F-box domain

    2. NM_001418106.1 → NP_001405035.1  F-box only protein 47 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596446

    3. NM_001418107.1 → NP_001405036.1  F-box only protein 47 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596446

    4. NM_001418108.1 → NP_001405037.1  F-box only protein 47 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596446
      UniProtKB/Swiss-Prot
      A2A6H3, B2RY07

    5. NM_001418109.1 → NP_001405038.1  F-box only protein 47 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL596446

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97741137..97775240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157021.1 → XP_036012914.1  F-box only protein 47 isoform X2

      Conserved Domains (1) summary
      pfam00646
      Location:47 → 78
      F-box; F-box domain

    2. XM_006534329.5 → XP_006534392.1  F-box only protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006534392.1

      UniProtKB/Swiss-Prot
      A2A6H3, B2RY07
      Conserved Domains (1) summary
      pfam00646
      Location:47 → 78
      F-box; F-box domain

    3. XM_006534328.5 → XP_006534391.1  F-box only protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006534391.1

      UniProtKB/Swiss-Prot
      A2A6H3, B2RY07
      Conserved Domains (1) summary
      pfam00646
      Location:47 → 78
      F-box; F-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A6H3.2 GenPept UniProtKB/Swiss-Prot:A2A6H3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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