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    Gpr20 G protein-coupled receptor 20 [ Mus musculus (house mouse) ]

    Gene ID: 239530, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr20provided by MGI
    Official Full Name
    G protein-coupled receptor 20provided by MGI
    Primary source
    MGI:MGI:2441803
    See related
    Ensembl:ENSMUSG00000045281 AllianceGenome:MGI:2441803
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430106B11Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cytosol. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human GPR20 (G protein-coupled receptor 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 7.9), duodenum adult (RPKM 2.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr20 in Genome Data Viewer
    Location:
    15 D3; 15 34.04 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (73560346..73579354, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (73688497..73707505, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:73342795-73343096 Neighboring gene DENN domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_38965 Neighboring gene solute carrier family 45, member 4 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73476060-73476361 Neighboring gene STARR-seq mESC enhancer starr_38967 Neighboring gene STARR-seq mESC enhancer starr_38972 Neighboring gene STARR-positive B cell enhancer mm9_chr15:73548453-73548754 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:73562951-73563152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:73565412-73565613 Neighboring gene STARR-seq mESC enhancer starr_38975 Neighboring gene protein tyrosine phosphatase 4a3 Neighboring gene predicted gene, 22106 Neighboring gene maestro heat-like repeat family member 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice. Robaye B, et al. Mol Pharmacol, 2003 Apr. PMID 12644577
    2. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    3. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
    4. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G-protein coupled receptor 20
    Names
    G protein-coupled receptor GPR20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173365.2 → NP_775541.1  G-protein coupled receptor 20

      See identical proteins and their annotated locations for NP_775541.1

      Status: PROVISIONAL

      Source sequence(s)
      AK040547
      Consensus CDS
      CCDS27518.1
      UniProtKB/Swiss-Prot
      Q80T63, Q8BYC4
      Related
      ENSMUSP00000063910.5, ENSMUST00000064166.5
      Conserved Domains (1) summary
      cd15163
      Location:53 → 307
      7tmA_GPR20; G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      73560346..73579354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520927.2 → XP_006520990.1  G-protein coupled receptor 20 isoform X1

      See identical proteins and their annotated locations for XP_006520990.1

      UniProtKB/Swiss-Prot
      Q80T63, Q8BYC4
      Conserved Domains (1) summary
      cd15163
      Location:53 → 307
      7tmA_GPR20; G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYC4.1 GenPept UniProtKB/Swiss-Prot:Q8BYC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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