Exoc4 exocyst complex component 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exoc4provided by MGI
Official Full Name: exocyst complex component 4provided by MGI
Primary source: MGI:MGI:1096376
See related: Ensembl:ENSMUSG00000029763 AllianceGenome:MGI:1096376
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sec8; Sec8l1
Summary: Enables PDZ domain binding activity. Acts upstream of or within paraxial mesoderm formation and protein transmembrane transport. Located in growth cone membrane; microvillus; and myelin sheath abaxonal region. Is expressed in several structures, including central nervous system; extraembryonic component; ganglia; and retina. Orthologous to human EXOC4 (exocyst complex component 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 5.5), CNS E11.5 (RPKM 5.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 14.59 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (33226025..33950914)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (33249090..33973979)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
Title: LRRK2 Modulates the Exocyst Complex Assembly by Interacting with Sec8.
CREG1 interacts with Sec8 to promote cardiomyogenic differentiation and cell-cell adhesion.
Title: CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion.
Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
Title: Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes.
Interaction of Discs large 1 (Dlg1) with the Sec8 exocyst component promotes membrane addition, whereas with myotubularin-related protein 2 (Mtmr2), negatively regulates membrane formation.
Title: Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination.
SAP102 interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Interactions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.
Title: NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex.
the exocyst complex serves to selectively regulate the docking of insulin-containing vesicles at sites of release close to the plasma membrane
Title: Mammalian exocyst complex is required for the docking step of insulin vesicle exocytosis.
Sec8 controls the directional movement of AMPA receptors towards synapses through PDZ-dependent interactions.
Title: Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sec8 (e-PCR), detects polymorphism
- UniSTS:144388

D6Mit309 (e-PCR), detects polymorphism
- UniSTS:130860

RH143015 (e-PCR)
- UniSTS:232262

D6Dcr5 (e-PCR), detects polymorphism
- UniSTS:507760

D6Mit270 (e-PCR), detects polymorphism
- UniSTS:116602

WI-14795 (e-PCR)
- UniSTS:64416

D6Mit206 (e-PCR), detects polymorphism
- UniSTS:130749

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi to transport vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane biogenesis	ISO Inferred from Sequence Orthology more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within paraxial mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in growth cone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in growth cone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: exocyst complex component 4

Names: SEC8-like 1; exocyst complex component Sec8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347089.2 → NP_001334018.1 exocyst complex component 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC132453, AC152961

Consensus CDS

CCDS85028.1

UniProtKB/TrEMBL

Q8C391, Q9CXE1

Related

ENSMUSP00000087859.5, ENSMUST00000090381.11
NM_009148.4 → NP_033174.2 exocyst complex component 4 isoform 1

See identical proteins and their annotated locations for NP_033174.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC132453, AC141927, AC152961, AC154020, AC155915

Consensus CDS

CCDS19987.1

UniProtKB/Swiss-Prot

O35382

UniProtKB/TrEMBL

Q69ZD1

Related

ENSMUSP00000051965.9, ENSMUST00000052266.15

Conserved Domains (1) summary

pfam04048
Location:57 → 143

Sec8_exocyst; Sec8 exocyst complex component specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

33226025..33950914

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241262.1 → XP_011239564.1 exocyst complex component 4 isoform X1

UniProtKB/TrEMBL

Q8CA11

Conserved Domains (1) summary

pfam04048
Location:57 → 143

Sec8_exocyst; Sec8 exocyst complex component specific domain