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    Krt12 keratin 12 [ Mus musculus (house mouse) ]

    Gene ID: 268482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt12provided by MGI
    Official Full Name
    keratin 12provided by MGI
    Primary source
    MGI:MGI:96687
    See related
    Ensembl:ENSMUSG00000020912 AllianceGenome:MGI:96687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    K12; Krt-12; Krt1-12
    Summary
    Predicted to enable structural molecule activity. Involved in cornea development in camera-type eye and morphogenesis of an epithelium. Acts upstream of or within epithelium development. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Is expressed in cornea; cornea epithelium; head; lower jaw molar; and upper jaw molar. Used to study Meesmann corneal dystrophy. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 12.9), frontal lobe adult (RPKM 10.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Krt12 in Genome Data Viewer
    Location:
    11 D; 11 62.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99306490..99313419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99415664..99422593, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene keratin 28 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247019-99247320 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247331-99247631 Neighboring gene keratin 10 Neighboring gene RIKEN cDNA A830036E02 gene Neighboring gene keratin 20 Neighboring gene keratin 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cornea-specific expression of K12 keratin during mouse development. Liu CY, et al. Curr Eye Res, 1993 Nov. PMID 7508359
    2. Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12. Liu CY, et al. J Biol Chem, 1994 Oct 7. PMID 7523376
    3. Targeted overexpression of TGF-α in the corneal epithelium of adult transgenic mice induces changes in anterior segment morphology and activates noncanonical Wnt signaling. Yuan Y, et al. Invest Ophthalmol Vis Sci, 2013 Mar 11. PMID 23412089, Free PMC Article
    4. Conjunctival epithelial cells can resurface denuded cornea, but do not transdifferentiate to express cornea-specific keratin 12 following removal of limbal epithelium in mouse. Moyer PD, et al. Differentiation, 1996 Mar. PMID 8935926
    5. Corneal epithelium-specific mouse keratin K12 promoter. Liu JJ, et al. Exp Eye Res, 1999 Mar. PMID 10079137

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data revealed that the early corneal epithelial progenitor cells expressing keratin-12 originated from limbus, and gave rise to the transit amplifying cells that migrated centripetally to differentiate into corneal epithelial cells
      Title: Study of corneal epithelial progenitor origin and the Yap1 requirement using keratin 12 lineage tracing transgenic mice.
    2. clonal limbal stem cells randomly activate Krt12 alleles in the process of terminal differentiation in cornea
      Title: Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cornea development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cornea development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cornea development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 12
    Names
    CK-12
    Keratin, type I cytoskeletal 12 (Cytokeratin 12)
    cytokeratin-12
    keratin complex 1, acidic, gene 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010661.2 → NP_034791.2  keratin, type I cytoskeletal 12

      Status: VALIDATED

      Source sequence(s)
      AK053362, AK143182, AL591165, CK627700
      Consensus CDS
      CCDS36306.1
      UniProtKB/Swiss-Prot
      A2A514, A2RRZ0, Q64291
      UniProtKB/TrEMBL
      Z4YJD9
      Related
      ENSMUSP00000017741.4, ENSMUST00000017741.4
      Conserved Domains (1) summary
      pfam00038
      Location:118 → 428
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      99306490..99313419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533413.2 → XP_006533476.1  keratin, type I cytoskeletal 12 isoform X1

      Conserved Domains (1) summary
      pfam00038
      Location:1 → 220
      Filament; Intermediate filament protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64291.2 GenPept UniProtKB/Swiss-Prot:Q64291

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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