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    Mmp27 matrix metallopeptidase 27 [ Mus musculus (house mouse) ]

    Gene ID: 234911, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mmp27provided by MGI
    Official Full Name
    matrix metallopeptidase 27provided by MGI
    Primary source
    MGI:MGI:3039232
    See related
    Ensembl:ENSMUSG00000070323 AllianceGenome:MGI:3039232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm180
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human MMP27 (matrix metallopeptidase 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Mmp27 in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7571397..7581886)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7571396..7581885)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 10 Neighboring gene predicted gene, 31751 Neighboring gene matrix metallopeptidase 8 Neighboring gene STARR-seq mESC enhancer starr_23215 Neighboring gene STARR-seq mESC enhancer starr_23216 Neighboring gene matrix metallopeptidase 20 (enamelysin) Neighboring gene STARR-seq mESC enhancer starr_23217 Neighboring gene expressed sequence AV064505 Neighboring gene protein kinase, interferon inducible double stranded RNA dependent activator pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of the entire MMP and TIMP gene families during mouse tissue development. Nuttall RK, et al. FEBS Lett, 2004 Apr 9. PMID 15063736
    2. Functional interactions between matrix metalloproteinases and glycosaminoglycans. Tocchi A, et al. FEBS J, 2013 May. PMID 23421805
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    matrix metalloproteinase-27
    Names
    matrix metalloproteinase 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310717.1 → NP_001297646.1  matrix metalloproteinase-27

      Status: VALIDATED

      Source sequence(s)
      AC115689, AK155813, AK159182
      Consensus CDS
      CCDS80952.1
      UniProtKB/TrEMBL
      D3YV89, D3Z6I1
      Related
      ENSMUSP00000113231.2, ENSMUST00000120900.8
      Conserved Domains (4) summary
      cd00094
      Location:291 → 480
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:120 → 276
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:120 → 276
      Peptidase_M10; Matrixin
      pfam01471
      Location:45 → 100
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7571397..7581886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001030289.1: Suppressed sequence

      Description
      NM_001030289.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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