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    Adam34l a disintegrin and metallopeptidase domain 34 like [ Mus musculus (house mouse) ]

    Gene ID: 384813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam34lprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 34 likeprovided by MGI
    Primary source
    MGI:MGI:3647273
    See related
    Ensembl:ENSMUSG00000050190 AllianceGenome:MGI:3647273
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5346; EG384813
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 2.0) See more
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    Genomic context

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    See Adam34l in Genome Data Viewer
    Location:
    8 A4; 8 24.05 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (44077926..44156461, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43624889..43703424, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 26A Neighboring gene STARR-seq mESC enhancer starr_21335 Neighboring gene STARR-seq mESC enhancer starr_21336 Neighboring gene a disintegrin and metallopeptidase domain 26B pseudogene Neighboring gene a disintegrin and metallopeptidase domain 34 Neighboring gene predicted gene 5347 Neighboring gene predicted gene 45488 Neighboring gene STARR-seq mESC enhancer starr_21337 Neighboring gene WW domain binding protein 11 pseudogene Neighboring gene peptidyl prolyl isomerase H pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metallopeptidase domain 34 like
    Names
    a disintegrin and metallopeptidase domain 26B pseudogene
    testase 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025240.2 → NP_001020411.1  a disintegrin and metallopeptidase domain 34 like

      See identical proteins and their annotated locations for NP_001020411.1

      Status: VALIDATED

      Source sequence(s)
      AC125369, AC131115
      Consensus CDS
      CCDS40332.1
      UniProtKB/TrEMBL
      Q7M766
      Related
      ENSMUSP00000058858.4, ENSMUST00000056023.5
      Conserved Domains (4) summary
      smart00608
      Location:492 → 628
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:207 → 395
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:416 → 488
      Disintegrin
      pfam01562
      Location:41 → 159
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      44077926..44156461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_019558.1: Suppressed sequence

      Description
      NG_019558.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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