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    Saa1 serum amyloid A 1 [ Mus musculus (house mouse) ]

    Gene ID: 20208, updated on 3-Dec-2024

    Summary

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    Official Symbol
    Saa1provided by MGI
    Official Full Name
    serum amyloid A 1provided by MGI
    Primary source
    MGI:MGI:98221
    See related
    Ensembl:ENSMUSG00000074115 AllianceGenome:MGI:98221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Saa2; Saa-1
    Summary
    Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within cholesterol metabolic process and response to bacterium. Located in extracellular space. Is expressed in extraembryonic component; intestine; liver; and placenta. Orthologous to human SAA1 (serum amyloid A1) and SAA2 (serum amyloid A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 137.3), large intestine adult (RPKM 79.1) and 1 other tissue See more
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    Genomic context

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    See Saa1 in Genome Data Viewer
    Location:
    7 B3; 7 30.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46389921..46392404, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46740497..46743181, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serum amyloid A 4 Neighboring gene serum amyloid A, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18868 Neighboring gene serum amyloid A 2 Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene STARR-seq mESC enhancer starr_18870 Neighboring gene STARR-positive B cell enhancer ABC_E6548

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the protein serum amyloid A in response to Aspergillus fumigatus in murine models of allergic airway inflammation. Moran G, et al. Rev Iberoam Micol, 2015 Jan-Mar. PMID 23603100
    2. Identification in human placentae of antigenic activity related to the amyloid serum protein SAA. Johnson PM, et al. Scand J Immunol, 1977. PMID 67636
    3. Degradation of amyloid A precursor protein SAA by macrophage cell lines obtained from amyloid resistant and susceptible strains of mice. Ham D, et al. Scand J Immunol, 1997 Apr. PMID 9105421
    4. Inflammation-dependent cerebral deposition of serum amyloid a protein in a mouse model of amyloidosis. Guo JT, et al. J Neurosci, 2002 Jul 15. PMID 12122052, Free PMC Article
    5. Intravenous cell therapy for acute renal failure with serum amyloid A protein-reprogrammed cells. Kelly KJ, et al. Am J Physiol Renal Physiol, 2010 Aug. PMID 20534870

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAA1 exacerbates pancreatic beta-cell dysfunction through activation of NF-kappaB signaling in high-fat diet-induced type 2 diabetes mice.
      Title: SAA1 exacerbates pancreatic β-cell dysfunction through activation of NF-κB signaling in high-fat diet-induced type 2 diabetes mice.
    2. SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-kappaB/p38/JNK and TGFbeta/Smad pathways.
      Title: SAA1 deficiency alleviates cardiac remodeling by inhibiting NF-κB/p38/JNK and TGFβ/Smad pathways.
    3. Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
      Title: Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.
    4. Mouse Bone Marrow Mesenchymal Stem Cells Inhibit Sepsis-Induced Lung Injury in Mice via Exosomal SAA1.
      Title: Mouse Bone Marrow Mesenchymal Stem Cells Inhibit Sepsis-Induced Lung Injury in Mice via Exosomal SAA1.
    5. Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-kappaB signaling pathway.
      Title: Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway.
    6. Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.
      Title: Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.
    7. Pro-Inflammatory Serum Amyloid a Stimulates Renal Dysfunction and Enhances Atherosclerosis in Apo E-Deficient Mice.
      Title: Pro-Inflammatory Serum Amyloid a Stimulates Renal Dysfunction and Enhances Atherosclerosis in Apo E-Deficient Mice.
    8. SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
      Title: SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
    9. Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
      Title: Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.
    10. Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density.
      Title: Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cholesterol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serum amyloid A-1 protein
    Names
    serum amyloid A 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357493.1 → NP_001344422.1  serum amyloid A-1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC090122
      Consensus CDS
      CCDS21284.1
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4
      Conserved Domains (1) summary
      pfam00277
      Location:23 → 122
      SAA; Serum amyloid A protein

    2. NM_001403085.1 → NP_001390014.1  serum amyloid A-1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC090122
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4

    3. NM_001403086.1 → NP_001390015.1  serum amyloid A-1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC090122
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4

    4. NM_009117.4 → NP_033143.1  serum amyloid A-1 protein precursor

      See identical proteins and their annotated locations for NP_033143.1

      Status: VALIDATED

      Source sequence(s)
      AC090122
      Consensus CDS
      CCDS21284.1
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4
      Related
      ENSMUSP00000119150.2, ENSMUST00000128088.4
      Conserved Domains (1) summary
      pfam00277
      Location:23 → 122
      SAA; Serum amyloid A protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46389921..46392404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05366.2 GenPept UniProtKB/Swiss-Prot:P05366

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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