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    Pon2 paraoxonase 2 [ Mus musculus (house mouse) ]

    Gene ID: 330260, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pon2provided by MGI
    Official Full Name
    paraoxonase 2provided by MGI
    Primary source
    MGI:MGI:106687
    See related
    Ensembl:ENSMUSG00000032667 AllianceGenome:MGI:106687
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330405I24Rik
    Summary
    Predicted to enable acyl-L-homoserine-lactone lactonohydrolase activity; arylesterase activity; and protein homodimerization activity. Predicted to be involved in lactone catabolic process and response to toxic substance. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Orthologous to human PON2 (paraoxonase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 37.9), liver E14 (RPKM 21.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pon2 in Genome Data Viewer
    Location:
    6 A1; 6 1.99 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (5264620..5298408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (5264620..5298345, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene paraoxonase 1 Neighboring gene STARR-seq mESC enhancer starr_15033 Neighboring gene paraoxonase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3642 Neighboring gene STARR-seq mESC enhancer starr_15035 Neighboring gene STARR-positive B cell enhancer ABC_E8094 Neighboring gene STARR-seq mESC enhancer starr_15037 Neighboring gene STARR-seq mESC enhancer starr_15042 Neighboring gene predicted gene, 38762 Neighboring gene STARR-seq mESC enhancer starr_15044 Neighboring gene ankyrin repeat and SOCS box-containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC68232

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-L-homoserine-lactone lactonohydrolase activity  
    enables acyl-L-homoserine-lactone lactonohydrolase activity  
    enables arylesterase activity  
    enables arylesterase activity  
    enables metal ion binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Process Evidence Code Pubs
    involved_in lactone catabolic process  
    involved_in lactone catabolic process  
    involved_in response to toxic substance  
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    serum paraoxonase/arylesterase 2
    Names
    A-esterase 2
    aromatic esterase 2
    serum aryldialkylphosphatase 2
    NP_899131.1
    XP_006505185.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183308.3NP_899131.1  serum paraoxonase/arylesterase 2

      See identical proteins and their annotated locations for NP_899131.1

      Status: VALIDATED

      Source sequence(s)
      AC023285, AC164289
      Consensus CDS
      CCDS19900.1
      UniProtKB/Swiss-Prot
      Q3TAD3, Q62086, Q8CFK3
      Related
      ENSMUSP00000062670.9, ENSMUST00000057792.9
      Conserved Domains (1) summary
      pfam01731
      Location:167252
      Arylesterase; Arylesterase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      5264620..5298408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505122.3XP_006505185.1  serum paraoxonase/arylesterase 2 isoform X1

      Conserved Domains (2) summary
      pfam01731
      Location:81166
      Arylesterase
      pfam08450
      Location:125210
      SGL; SMP-30/Gluconolaconase/LRE-like region
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