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    Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 75750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc10a6provided by MGI
    Official Full Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 6provided by MGI
    Primary source
    MGI:MGI:1923000
    See related
    Ensembl:ENSMUSG00000029321 AllianceGenome:MGI:1923000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Soat; 8430417G17Rik
    Summary
    Predicted to enable bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-dependent organic anion transport. Predicted to be located in membrane. Is expressed in metanephros. Orthologous to human SLC10A6 (solute carrier family 10 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 9.0), subcutaneous fat pad adult (RPKM 3.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc10a6 in Genome Data Viewer
    Location:
    5 E5; 5 50.45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (103753583..103777152, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (103605711..103629403, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30443 Neighboring gene protein tyrosine phosphatase, non-receptor type 13 Neighboring gene RIKEN cDNA 1700016H13 gene Neighboring gene STARR-seq mESC enhancer starr_13780 Neighboring gene predicted gene, 42138 Neighboring gene predicted gene, 25721

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional characterization of the mouse sodium-dependent organic anion transporter Soat (Slc10a6). Grosser G, et al. J Steroid Biochem Mol Biol, 2013 Nov. PMID 23562556
    2. Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. Bakhaus K, et al. J Steroid Biochem Mol Biol, 2018 May. PMID 28743544
    3. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slc10a6 role in the supply of steroids in the testis and consequently for spermatogenesis and fertility.
      Title: Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149979

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium-dependent organic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium-dependent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-dependent organic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-dependent organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent organic anion transporter
    Names
    solute carrier family 10 member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029415.3 → NP_083691.1  sodium-dependent organic anion transporter

      See identical proteins and their annotated locations for NP_083691.1

      Status: VALIDATED

      Source sequence(s)
      AC161169
      Consensus CDS
      CCDS19477.1
      UniProtKB/Swiss-Prot
      B2RTH4, Q9CXB2
      Related
      ENSMUSP00000031263.2, ENSMUST00000031263.2
      Conserved Domains (1) summary
      TIGR00841
      Location:32 → 312
      bass; bile acid transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      103753583..103777152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535278.4 → XP_006535341.1  sodium-dependent organic anion transporter isoform X1

      Conserved Domains (1) summary
      cl19217
      Location:1 → 184
      SBF; Sodium Bile acid symporter family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXB2.1 GenPept UniProtKB/Swiss-Prot:Q9CXB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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