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    Trim50 tripartite motif-containing 50 [ Mus musculus (house mouse) ]

    Gene ID: 215061, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trim50provided by MGI
    Official Full Name
    tripartite motif-containing 50provided by MGI
    Primary source
    MGI:MGI:2664992
    See related
    Ensembl:ENSMUSG00000053388 AllianceGenome:MGI:2664992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within regulation of establishment of protein localization. Located in aggresome. Is expressed in brain; liver; and reproductive system. Orthologous to several human genes including TRIM50 (tripartite motif containing 50). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward stomach adult (RPKM 20.3) See more
    Orthologs
    human all
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    Genomic context

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    See Trim50 in Genome Data Viewer
    Location:
    5 G2; 5 75.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135380738..135396744)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135351884..135367890)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 9 Neighboring gene FK506 binding protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E9263 Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene nuclear pore membrane protein 121 Neighboring gene microRNA 7033

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells. Nishi M, et al. J Biol Chem, 2012 Sep 28. PMID 22872646, Free PMC Article
    2. Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. Li HH, et al. EMBO Mol Med, 2009 Apr. PMID 20049703, Free PMC Article
    3. Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression. Strogantsev R, et al. Genome Biol, 2015 May 30. PMID 26025256, Free PMC Article
    4. TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization. Lin Y, et al. EMBO Rep, 2022 Nov 7. PMID 36178239, Free PMC Article
    5. TRIM50 regulates Beclin 1 proautophagic activity. Fusco C, et al. Biochim Biophys Acta Mol Cell Res, 2018 Jun. PMID 29604308

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.
      Title: TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization.
    2. TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity.
      Title: TRIM50 regulates Beclin 1 proautophagic activity.
    3. TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells
      Title: TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIM50
    Names
    RING-type E3 ubiquitin transferase TRIM50
    tripartite motif-containing protein 50
    NP_001333674.1
    NP_839971.1
    XP_006504474.1
    XP_006504475.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346745.1 → NP_001333674.1  E3 ubiquitin-protein ligase TRIM50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074359
      Consensus CDS
      CCDS89996.1
      UniProtKB/TrEMBL
      A1L3C6, E9PVV5
      Related
      ENSMUSP00000106811.3, ENSMUST00000111180.9
      Conserved Domains (4) summary
      cd13743
      Location:283 → 471
      SPRY_PRY_TRIM50; PRY/SPRY domain in tripartite motif-binding protein 50 (TRIM50)
      cd16605
      Location:14 → 58
      RING-HC_TRIM50_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM50, TRIM73, TRIM74 and similar proteins
      pfam12761
      Location:131 → 231
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl00034
      Location:88 → 125
      Bbox_SF; B-box-type zinc finger superfamily

    2. NM_178240.3 → NP_839971.1  E3 ubiquitin-protein ligase TRIM50 isoform 1

      See identical proteins and their annotated locations for NP_839971.1

      Status: VALIDATED

      Source sequence(s)
      AC074359
      Consensus CDS
      CCDS19739.1
      UniProtKB/Swiss-Prot
      Q810I2
      UniProtKB/TrEMBL
      A1L3C6
      Related
      ENSMUSP00000066662.4, ENSMUST00000065785.4
      Conserved Domains (4) summary
      TIGR00618
      Location:108 → 259
      sbcc; exonuclease SbcC
      cd13743
      Location:282 → 470
      SPRY_PRY_TRIM50; PRY/SPRY domain in tripartite motif-binding protein 50 (TRIM50)
      cd16605
      Location:14 → 58
      RING-HC_TRIM50_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM50, TRIM73, TRIM74 and similar proteins
      cl00034
      Location:88 → 125
      Bbox_SF; B-box-type zinc finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135380738..135396744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504411.4 → XP_006504474.1  E3 ubiquitin-protein ligase TRIM50 isoform X1

      UniProtKB/TrEMBL
      A1L3C6, E9PVV5
      Conserved Domains (4) summary
      cd13743
      Location:283 → 471
      SPRY_PRY_TRIM50; PRY/SPRY domain in tripartite motif-binding protein 50 (TRIM50)
      cd16605
      Location:14 → 58
      RING-HC_TRIM50_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM50, TRIM73, TRIM74 and similar proteins
      pfam12761
      Location:131 → 231
      End3; Actin cytoskeleton-regulatory complex protein END3
      cl00034
      Location:88 → 125
      Bbox_SF; B-box-type zinc finger superfamily

    2. XM_006504412.4 → XP_006504475.1  E3 ubiquitin-protein ligase TRIM50 isoform X2

      See identical proteins and their annotated locations for XP_006504475.1

      UniProtKB/Swiss-Prot
      Q810I2
      UniProtKB/TrEMBL
      A1L3C6
      Conserved Domains (4) summary
      TIGR00618
      Location:108 → 259
      sbcc; exonuclease SbcC
      cd13743
      Location:282 → 470
      SPRY_PRY_TRIM50; PRY/SPRY domain in tripartite motif-binding protein 50 (TRIM50)
      cd16605
      Location:14 → 58
      RING-HC_TRIM50_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM50, TRIM73, TRIM74 and similar proteins
      cl00034
      Location:88 → 125
      Bbox_SF; B-box-type zinc finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810I2.1 GenPept UniProtKB/Swiss-Prot:Q810I2

    Gene LinkOut

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