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    Bche butyrylcholinesterase [ Mus musculus (house mouse) ]

    Gene ID: 12038, updated on 3-Dec-2024

    Summary

    Official Symbol
    Bcheprovided by MGI
    Official Full Name
    butyrylcholinesteraseprovided by MGI
    Primary source
    MGI:MGI:894278
    See related
    Ensembl:ENSMUSG00000027792 AllianceGenome:MGI:894278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C730038G20Rik
    Summary
    Enables acetylcholinesterase activity. Predicted to be involved in several processes, including acetylcholine catabolic process; neuroblast differentiation; and response to folic acid. Located in endoplasmic reticulum and nuclear envelope lumen. Is expressed in several structures, including adrenal gland; alimentary system; ear; liver; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); epilepsy; and inherited metabolic disorder (multiple). Orthologous to human BCHE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 7.4), liver E18 (RPKM 6.0) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bche in Genome Data Viewer
    Location:
    3 E3; 3 33.61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (73543138..73615767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (73635805..73708436, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SLIT and NTRK-like family, member 3 Neighboring gene predicted gene, 20754 Neighboring gene STARR-seq mESC enhancer starr_07954 Neighboring gene STARR-seq mESC enhancer starr_07955 Neighboring gene STARR-seq mESC enhancer starr_07956 Neighboring gene RIKEN cDNA 4930509J09 gene Neighboring gene STARR-seq mESC enhancer starr_07957 Neighboring gene STARR-seq mESC enhancer starr_07958 Neighboring gene STARR-seq mESC enhancer starr_07959 Neighboring gene STARR-seq mESC enhancer starr_07960 Neighboring gene STARR-seq mESC enhancer starr_07961 Neighboring gene STARR-seq mESC enhancer starr_07962 Neighboring gene STARR-seq mESC enhancer starr_07963 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 20356

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107651

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholinesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholinesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables choline binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables choline binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholinesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cholinesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acetylcholine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in choline metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in choline metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in choline metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuroblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to folic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to folic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cholinesterase
    Names
    acylcholine acylhydrolase
    butyrylcholine esterase
    choline esterase II
    pseudocholinesterase
    NP_033868.3
    XP_011238302.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428371.1NP_001415300.1  cholinesterase isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC099722
      UniProtKB/TrEMBL
      Q499C7
    2. NM_009738.4NP_033868.3  cholinesterase isoform 1 precursor

      See identical proteins and their annotated locations for NP_033868.3

      Status: VALIDATED

      Source sequence(s)
      AC099722
      Consensus CDS
      CCDS17411.1
      UniProtKB/Swiss-Prot
      Q03311, Q543J3
      UniProtKB/TrEMBL
      Q499C7
      Related
      ENSMUSP00000029367.6, ENSMUST00000029367.6
      Conserved Domains (3) summary
      COG0657
      Location:126278
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:27551
      COesterase; Carboxylesterase family
      pfam08674
      Location:566600
      AChE_tetra; Acetylcholinesterase tetramerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      73543138..73615767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240000.3XP_011238302.1  cholinesterase isoform X1

      Conserved Domains (2) summary
      pfam00135
      Location:46563
      COesterase; Carboxylesterase family
      pfam08674
      Location:578612
      AChE_tetra; Acetylcholinesterase tetramerisation domain