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    Zfp408 zinc finger protein 408 [ Mus musculus (house mouse) ]

    Gene ID: 381410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp408provided by MGI
    Official Full Name
    zinc finger protein 408provided by MGI
    Primary source
    MGI:MGI:2685857
    See related
    Ensembl:ENSMUSG00000075040 AllianceGenome:MGI:2685857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1011
    Summary
    Predicted to enable DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in cerebral cortex ventricular layer and cortical plate. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 6 and retinitis pigmentosa 72. Orthologous to human ZNF408 (zinc finger protein 408). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.6), ovary adult (RPKM 8.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp408 in Genome Data Viewer
    Location:
    2 E1; 2 50.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91473101..91480372, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91642756..91650051, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91475064-91475265 Neighboring gene coagulation factor II Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91486007-91486292 Neighboring gene STARR-positive B cell enhancer ABC_E1007 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene Rho GTPase activating protein 1 Neighboring gene STARR-seq mESC enhancer starr_05121 Neighboring gene autophagy related 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 408

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033451.4 → NP_001028623.1  zinc finger protein 408 isoform 2

      See identical proteins and their annotated locations for NP_001028623.1

      Status: VALIDATED

      Source sequence(s)
      AL691489
      Consensus CDS
      CCDS16436.1
      UniProtKB/TrEMBL
      B7ZP32, Q3V1D8
      Related
      ENSMUSP00000106965.2, ENSMUST00000111333.2
      Conserved Domains (3) summary
      COG5048
      Location:158 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:361 → 381
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:3 → 72
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

    2. NM_001347175.3 → NP_001334104.1  zinc finger protein 408 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL691489
      Consensus CDS
      CCDS84551.1
      UniProtKB/TrEMBL
      B7ZP32, H7BX78
      Related
      ENSMUSP00000097301.4, ENSMUST00000099714.10

    3. NM_001410208.1 → NP_001397137.1  zinc finger protein 408 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      B7ZP32, Q3V1D8

    4. NM_001410209.1 → NP_001397138.1  zinc finger protein 408 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      B7ZP32, Q3V1D8

    5. NM_001410210.1 → NP_001397139.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    6. NM_001410211.1 → NP_001397140.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    7. NM_001410212.1 → NP_001397141.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    8. NM_001410213.1 → NP_001397142.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    9. NM_001410214.1 → NP_001397143.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    10. NM_001410215.1 → NP_001397144.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    11. NM_001410216.1 → NP_001397145.1  zinc finger protein 408 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      Q3UYR8

    12. NM_001410217.1 → NP_001397146.1  zinc finger protein 408 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      B7ZP32

    13. NM_001410218.1 → NP_001397147.1  zinc finger protein 408 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL691489
      UniProtKB/TrEMBL
      B7ZP32

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91473101..91480372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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