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    Rbp4 retinol binding protein 4, plasma [ Mus musculus (house mouse) ]

    Gene ID: 19662, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbp4provided by MGI
    Official Full Name
    retinol binding protein 4, plasmaprovided by MGI
    Primary source
    MGI:MGI:97879
    See related
    Ensembl:ENSMUSG00000024990 AllianceGenome:MGI:97879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbp-4
    Summary
    Enables retinol binding activity. Involved in several processes, including embryonic morphogenesis; heart development; and reproductive structure development. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; retinoid metabolic process; and terpenoid transport. Located in extracellular space. Is expressed in several structures, including adipose tissue; brain; genitourinary system; gut; and hindlimb. Human ortholog(s) of this gene implicated in coronary artery disease and type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 1256.0), liver E18 (RPKM 733.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Rbp4 in Genome Data Viewer
    Location:
    19 C2; 19 32.75 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (38105068..38113769, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (38116620..38125321, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 55 Neighboring gene predicted gene, 23300 Neighboring gene free fatty acid receptor 4 Neighboring gene predicted gene, 32440 Neighboring gene phosphodiesterase 6C, cGMP specific, cone, alpha prime Neighboring gene predicted gene, 52398

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular carrier activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables retinol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables retinol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinol transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in embryonic organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of gastrointestinal epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of phototransduction, visible light IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of immunoglobulin production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinal metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within retinol transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in urinary bladder development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in uterus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vagina development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vitamin A import into cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    retinol-binding protein 4
    Names
    PRBP
    RBP
    plasma retinol-binding protein
    retinol binding protein 4, cellular

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159487.1NP_001152959.1  retinol-binding protein 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC101774, AK008765, AW113115, BY769772
      Consensus CDS
      CCDS50430.1
      UniProtKB/TrEMBL
      H7BWY6
      Related
      ENSMUSP00000025951.7, ENSMUST00000025951.14
      Conserved Domains (1) summary
      cd00743
      Location:66236
      lipocalin_RBP_like; retinol-binding protein 4 and similar proteins
    2. NM_011255.3NP_035385.1  retinol-binding protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_035385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK008765, AW113115, BY112174
      Consensus CDS
      CCDS29784.1
      UniProtKB/Swiss-Prot
      P70357, Q00724, Q566I5
      UniProtKB/TrEMBL
      Q3TF08
      Related
      ENSMUSP00000107954.3, ENSMUST00000112335.4
      Conserved Domains (1) summary
      cd00743
      Location:22192
      lipocalin_RBP_like; retinol-binding protein 4 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      38105068..38113769 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)