Abcc2 ATP-binding cassette, sub-family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcc2provided by MGI
Official Full Name: ATP-binding cassette, sub-family member 2provided by MGI
Primary source: MGI:MGI:1352447
See related: Ensembl:ENSMUSG00000025194 AllianceGenome:MGI:1352447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mrp2; cMRP; Abc30; Cmoat
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the canalicular surface of the hepatocyte and in biliary transport, and appears to contribute to drug resistance in mammalian cells. Several different mutations in the human gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Alternative splice variants have been observed for this gene; however, they have not been fully described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver adult (RPKM 39.0), kidney adult (RPKM 24.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.67 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43770747..43826771)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (43782308..43838332)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression.
Title: FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression.
Reduced Mrp2 surface availability as PI3Kgamma-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis.
Title: Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis.
The authors conclude that MRP1 assists in depression of polymorphonuclear cell (PMN) migration by effluxing a molecule that inhibits the proinflammatory effects of MRP2 activity.
Title: Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.
Circadian oscillation of Mrp2 protein expression was clearly observed in the mouse liver with levels down at the light phase and up at the dark phase.
Title: Circadian Clock Is Involved in Regulation of Hepatobiliary Transport Mediated by Multidrug Resistance-Associated Protein 2.
Biotinylation and streptavidin pull-down assays confirmed that CAL dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL interacts with Mrp2 and is a negative regulator of Mrp2 expression.
Title: CFTR-associated ligand is a negative regulator of Mrp2 expression.
Deficiency in Mrp2 lowers platinum excretion and increases susceptibility to kidney injury, which can be rescued by the human MRP2 ortholog.
Title: Transgenic expression of the human MRP2 transporter reduces cisplatin accumulation and nephrotoxicity in Mrp2-null mice.
In Bcrp1;Mrp2;Mrp3(-/-), but not Bcrp1;Mdr1a/b;Mrp(-/-) mice.
Title: Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Cd or H(2)O(2) exposure increased the expression of key transport genes, Mrp1 and Mrp2, in WT cells but not in metallothionein-null cells.
Title: Metallothionein blocks oxidative DNA damage in vitro.
hepatic transporters Ntcp and Mrp2 are downregulated in rodent models of necrotizing enterocolitis
Title: The hepatic bile acid transporters Ntcp and Mrp2 are downregulated in experimental necrotizing enterocolitis.
Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX.
Title: Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

General gene information

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Markers

Abcc2 (e-PCR), detects polymorphism
- UniSTS:141361

Abcc1 (e-PCR), detects polymorphism
- UniSTS:532532

AI173996 (e-PCR)
- UniSTS:160844

PMC86435P2 (e-PCR)
- UniSTS:273524

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables bilirubin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables bilirubin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in benzylpenicillin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in bilirubin transport	IEA Inferred from Electronic Annotation more info
involved_in bilirubin transport	ISO Inferred from Sequence Orthology more info
involved_in canalicular bile acid transport	ISO Inferred from Sequence Orthology more info
involved_in detoxification of mercury ion	ISO Inferred from Sequence Orthology more info
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in leukotriene transport	IEA Inferred from Electronic Annotation more info
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
involved_in mercury ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in organic anion transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic export from cell	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic export from cell	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in intercellular canaliculus	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular canaliculus	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 2

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multispecific organic anion transporter 1; multidrug resistance protein 2; multidrug resistance-associated protein 2

NP_038834.2

EC 7.6.2.2

EC 7.6.2.3

XP_006526688.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013806.2 → NP_038834.2 ATP-binding cassette sub-family C member 2

See identical proteins and their annotated locations for NP_038834.2

Status: VALIDATED

Source sequence(s)

AC132251, AC141888, AF282773

Consensus CDS

CCDS29838.1

UniProtKB/Swiss-Prot

Q8VI46, Q8VI47

UniProtKB/TrEMBL

Q9JIH8

Related

ENSMUSP00000026208.5, ENSMUST00000026208.6

Conserved Domains (1) summary

TIGR00957
Location:10 → 1535

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

43770747..43826771

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526625.4 → XP_006526688.1 ATP-binding cassette sub-family C member 2 isoform X1

UniProtKB/TrEMBL

Q9JIH8

Conserved Domains (1) summary

TIGR00957
Location:17 → 1487

MRP_assoc_pro; multi drug resistance-associated protein (MRP)