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    Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 13082, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyp26a1provided by MGI
    Official Full Name
    cytochrome P450, family 26, subfamily a, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1096359
    See related
    Ensembl:ENSMUSG00000024987 AllianceGenome:MGI:1096359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAH; Cyp26; P450RA; P450RAI
    Summary
    Enables retinoic acid 4-hydroxylase activity. Involved in cellular response to retinoic acid and retinoic acid catabolic process. Acts upstream of or within anterior/posterior pattern specification; central nervous system development; and neural crest cell development. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and sensory organ. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 38.3) and ovary adult (RPKM 6.7) See more
    Orthologs
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    Genomic context

    See Cyp26a1 in Genome Data Viewer
    Location:
    19 C2; 19 32.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37686186..37689984)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37697738..37701536)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 6 Neighboring gene predicted gene, 41842 Neighboring gene STARR-seq mESC enhancer starr_46060 Neighboring gene STARR-seq mESC enhancer starr_46061 Neighboring gene STARR-seq mESC enhancer starr_46062 Neighboring gene predicted gene, 32342 Neighboring gene cytochrome P450, family 26, subfamily c, polypeptide 1 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC13860

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural crest cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in retinoic acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoic acid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in retinoic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinoic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of retinoic acid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within retinoic acid receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 26A1
    Names
    cytochrome P450, 26, retinoic acid A1
    cytochrome P450RAI
    retinoic acid 4-hydroxylase
    retinoic acid hydrolase
    retinoic acid-metabolizing cytochrome
    NP_031837.2
    XP_017173542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007811.2NP_031837.2  cytochrome P450 26A1

      See identical proteins and their annotated locations for NP_031837.2

      Status: VALIDATED

      Source sequence(s)
      AA239785, CB574526, CJ217321, CK626921
      Consensus CDS
      CCDS29780.1
      UniProtKB/Swiss-Prot
      O55127, Q9R1F4
      UniProtKB/TrEMBL
      A0A0R4J061
      Related
      ENSMUSP00000025946.6, ENSMUST00000025946.7
      Conserved Domains (1) summary
      cl12078
      Location:43491
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      37686186..37689984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318053.2XP_017173542.1  cytochrome P450 26A1 isoform X1

      UniProtKB/Swiss-Prot
      O55127, Q9R1F4
      Conserved Domains (1) summary
      cl12078
      Location:4422
      p450; Cytochrome P450