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    Il33 interleukin 33 [ Mus musculus (house mouse) ]

    Gene ID: 77125, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il33provided by MGI
    Official Full Name
    interleukin 33provided by MGI
    Primary source
    MGI:MGI:1924375
    See related
    Ensembl:ENSMUSG00000024810 AllianceGenome:MGI:1924375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-33; Il1f11; NF-HEV; 9230117N10Rik
    Summary
    Enables cytokine activity and interleukin-33 receptor binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; regulation of gene expression; and regulation of inflammatory response. Acts upstream of or within several processes, including negative regulation of macrophage proliferation; positive regulation of cellular defense response; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Is active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in candidiasis; inflammatory bowel disease; and peptic ulcer disease. Orthologous to human IL33 (interleukin 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 13.9), cerebellum adult (RPKM 10.6) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Il33 in Genome Data Viewer
    Location:
    19 C1; 19 24.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29902513..29938118)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29925113..29960718)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RAN binding protein 6 Neighboring gene STARR-seq mESC enhancer starr_45896 Neighboring gene STARR-seq mESC enhancer starr_45897 Neighboring gene predicted gene, 41832 Neighboring gene predicted gene, 36209 Neighboring gene STARR-seq mESC enhancer starr_45899 Neighboring gene predicted gene, 26046 Neighboring gene STARR-seq mESC enhancer starr_45900 Neighboring gene tumor protein D52-like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-33 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-33-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microglial cell activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microglial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T-helper 1 type immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of leukocyte migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of macrophage proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type II interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of CD80 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of CD86 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MHC class I biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cellular defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of immunoglobulin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-13 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-5 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type 2 immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type 2 immune response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of type 2 immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-33
    Names
    nuclear factor from high endothelial venules

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164724.2NP_001158196.1  interleukin-33 isoform 1

      See identical proteins and their annotated locations for NP_001158196.1

      Status: VALIDATED

      Source sequence(s)
      AC111048, AK075849, AK163464, CJ191135
      Consensus CDS
      CCDS29740.1
      UniProtKB/Swiss-Prot
      Q2YEJ4, Q3TQN0, Q8BVZ5, Q99L46
      UniProtKB/TrEMBL
      H3BLN5
      Related
      ENSMUSP00000025724.9, ENSMUST00000025724.9
      Conserved Domains (1) summary
      pfam15095
      Location:5264
      IL33; Interleukin 33
    2. NM_001360725.1NP_001347654.1  interleukin-33 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC111048, AC157785
      Consensus CDS
      CCDS29740.1
      UniProtKB/Swiss-Prot
      Q2YEJ4, Q3TQN0, Q8BVZ5, Q99L46
      UniProtKB/TrEMBL
      H3BLN5
      Conserved Domains (1) summary
      pfam15095
      Location:5264
      IL33; Interleukin 33
    3. NM_133775.3NP_598536.2  interleukin-33 isoform 1

      See identical proteins and their annotated locations for NP_598536.2

      Status: VALIDATED

      Source sequence(s)
      AC111048, AC157785, AK163464
      Consensus CDS
      CCDS29740.1
      UniProtKB/Swiss-Prot
      Q2YEJ4, Q3TQN0, Q8BVZ5, Q99L46
      UniProtKB/TrEMBL
      H3BLN5
      Related
      ENSMUSP00000113829.3, ENSMUST00000120388.9
      Conserved Domains (1) summary
      pfam15095
      Location:5264
      IL33; Interleukin 33

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      29902513..29938118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161730.1XP_036017623.1  interleukin-33 isoform X1

      UniProtKB/Swiss-Prot
      Q2YEJ4, Q3TQN0, Q8BVZ5, Q99L46
      UniProtKB/TrEMBL
      H3BLN5
      Conserved Domains (1) summary
      pfam15095
      Location:5264
      IL33; Interleukin 33
    2. XM_006527463.4XP_006527526.1  interleukin-33 isoform X1

      See identical proteins and their annotated locations for XP_006527526.1

      UniProtKB/Swiss-Prot
      Q2YEJ4, Q3TQN0, Q8BVZ5, Q99L46
      UniProtKB/TrEMBL
      H3BLN5
      Conserved Domains (1) summary
      pfam15095
      Location:5264
      IL33; Interleukin 33