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    Cxxc1 CXXC finger protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 74322, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cxxc1provided by MGI
    Official Full Name
    CXXC finger protein 1provided by MGI
    Primary source
    MGI:MGI:1921572
    See related
    Ensembl:ENSMUSG00000024560 AllianceGenome:MGI:1921572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cfp1; Cgbp; PHF18; 2410002I16Rik; 5830420C16Rik
    Summary
    Enables methylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Located in nuclear matrix. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.1), spleen adult (RPKM 21.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cxxc1 in Genome Data Viewer
    Location:
    18 E2; 18 50.7 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74349283..74354564)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74216212..74221493)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57658 Neighboring gene STARR-positive B cell enhancer ABC_E1520 Neighboring gene STARR-seq mESC enhancer starr_45003 Neighboring gene spindle and kinetochore associated complex subunit 1 Neighboring gene STARR-seq mESC enhancer starr_45004 Neighboring gene STARR-positive B cell enhancer ABC_E2512 Neighboring gene ribosomal protein L10A pseudogene Neighboring gene methyl-CpG binding domain protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unmethylated CpG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Set1C/COMPASS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CXXC-type zinc finger protein 1
    Names
    CXXC finger 1 (PHD domain)
    CpG binding protein
    PHD finger and CXXC domain-containing protein 1
    cpG-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378844.1NP_001365773.1  CXXC-type zinc finger protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC133186
      UniProtKB/TrEMBL
      Q3UIZ4
      Conserved Domains (3) summary
      cd15553
      Location:2873
      PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
      pfam02008
      Location:166212
      zf-CXXC; CXXC zinc finger domain
      pfam12269
      Location:410644
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain
    2. NM_028868.3NP_083144.1  CXXC-type zinc finger protein 1 isoform 1

      See identical proteins and their annotated locations for NP_083144.1

      Status: VALIDATED

      Source sequence(s)
      AC133186
      Consensus CDS
      CCDS50320.1
      UniProtKB/Swiss-Prot
      Q9CWW7
      UniProtKB/TrEMBL
      Q3UIZ4, Q541B1
      Related
      ENSMUSP00000025444.7, ENSMUST00000025444.8
      Conserved Domains (3) summary
      pfam02008
      Location:166212
      zf-CXXC; CXXC zinc finger domain
      cd15553
      Location:2873
      PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
      pfam12269
      Location:406640
      zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      74349283..74354564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)