Nipsnap1 nipsnap homolog 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nipsnap1provided by MGI
Official Full Name: nipsnap homolog 1provided by MGI
Primary source: MGI:MGI:1278344
See related: Ensembl:ENSMUSG00000034285 AllianceGenome:MGI:1278344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable protein-macromolecule adaptor activity. Involved in mitophagy and sensory perception of pain. Located in membrane and mitochondrion. Is active in synaptic membrane. Is expressed in several structures, including gonad; gut; nervous system; submandibular gland primordium; and tooth. Orthologous to human NIPSNAP1 (nipsnap homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 20.7), kidney adult (RPKM 12.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.07 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (4823951..4844201)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (4873951..4894201)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NIPSNAP1 is an interacting molecule of NST and plays a crucial role in pain transmission.
Title: Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.
This study presents the first physiological function of Nipsnap1 as an associated protein inhibiting transient receptor potential vanilloid channel 6 activity that possibly exerts its effect directly at the plasma membrane.
Title: Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity.
Data suggest that amyloid precursor proteins may affect mitochondrial function through a direct interaction with NIPSNAP1 as well as with other mitochondrial proteins.
Title: Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AJ001260 (e-PCR)
- UniSTS:160060

D0Uia24 (e-PCR)
- UniSTS:518269

AI327362 (e-PCR)
- UniSTS:180138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein NipSnap homolog 1

Names: 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.