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    Rnf2 ring finger protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 19821, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf2provided by MGI
    Official Full Name
    ring finger protein 2provided by MGI
    Primary source
    MGI:MGI:1101759
    See related
    Ensembl:ENSMUSG00000026484 AllianceGenome:MGI:1101759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dinG; Ring1B
    Summary
    Enables chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Involved in germ cell development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within anterior/posterior axis specification; gastrulation with mouth forming second; and mitotic cell cycle. Located in euchromatin; nuclear body; and sex chromatin. Part of PRC1 complex. Is active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; limb; and retina. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 21.3), placenta adult (RPKM 21.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnf2 in Genome Data Viewer
    Location:
    1 G1; 1 64.15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151345159..151376562, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151469398..151500991, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E994 Neighboring gene STARR-positive B cell enhancer ABC_E5817 Neighboring gene STARR-seq mESC enhancer starr_02618 Neighboring gene tRNA methyltransferase 1 like Neighboring gene STARR-seq mESC enhancer starr_02619 Neighboring gene microRNA 7682 Neighboring gene STARR-seq mESC enhancer starr_02624 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene niban apoptosis regulator 1 Neighboring gene STARR-seq mESC enhancer starr_02626 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153553362-153553663

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RING-like zinc finger domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AK119 ubiquitin ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect chromatin organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within_positive_effect chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epigenetic regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within_negative_effect gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PRC1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sex chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RING2
    Names
    RING finger protein 1B
    RING-type E3 ubiquitin transferase RING2
    NP_001347773.2
    NP_001347774.1
    NP_001347776.1
    NP_001407869.1
    NP_001407870.1
    NP_035407.1
    XP_036018760.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360844.2NP_001347773.2  E3 ubiquitin-protein ligase RING2

      Status: VALIDATED

      Source sequence(s)
      AC115060, AC165946
      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    2. NM_001360845.2NP_001347774.1  E3 ubiquitin-protein ligase RING2

      Status: VALIDATED

      Source sequence(s)
      AC115060, AC165946
      Consensus CDS
      CCDS15362.1
      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)
    3. NM_001360847.2NP_001347776.1  E3 ubiquitin-protein ligase RING2

      Status: VALIDATED

      Source sequence(s)
      AC115060, AC165946
      Consensus CDS
      CCDS15362.1
      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
      Related
      ENSMUSP00000140896.2, ENSMUST00000187048.7
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)
    4. NM_001420940.1NP_001407869.1  E3 ubiquitin-protein ligase RING2

      Status: VALIDATED

      Source sequence(s)
      AC115060, AC165946
      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    5. NM_001420941.1NP_001407870.1  E3 ubiquitin-protein ligase RING2

      Status: VALIDATED

      Source sequence(s)
      AC115060, AC165946
      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
    6. NM_011277.4NP_035407.1  E3 ubiquitin-protein ligase RING2

      See identical proteins and their annotated locations for NP_035407.1

      Status: VALIDATED

      Source sequence(s)
      AC115060, AC165946
      Consensus CDS
      CCDS15362.1
      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
      Related
      ENSMUSP00000075476.5, ENSMUST00000076110.11
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      151345159..151376562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162867.1XP_036018760.1  E3 ubiquitin-protein ligase RING2 isoform X2

      UniProtKB/Swiss-Prot
      O35699, O35729, Q4FJV5, Q8C1X8, Q9CQJ4
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)