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    Nmnat2 nicotinamide nucleotide adenylyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 226518, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nmnat2provided by MGI
    Official Full Name
    nicotinamide nucleotide adenylyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2444155
    See related
    Ensembl:ENSMUSG00000042751 AllianceGenome:MGI:2444155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PNAT1; PNAT2; D030041I09Rik
    Summary
    Predicted to enable nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Predicted to be involved in NAD biosynthetic process and negative regulation of cytoplasmic translation. Located in late endosome; synapse; and trans-Golgi network. Is expressed in alimentary system; nervous system; and sensory organ. Orthologous to human NMNAT2 (nicotinamide nucleotide adenylyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 20.5), cortex adult (RPKM 13.6) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nmnat2 in Genome Data Viewer
    Location:
    1 G3; 1 65.15 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152830532..152995012)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152954781..153119266)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700040K01 gene Neighboring gene STARR-seq mESC enhancer starr_02655 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02656 Neighboring gene STARR-seq mESC enhancer starr_02657 Neighboring gene STARR-seq mESC enhancer starr_02664 Neighboring gene STARR-seq mESC enhancer starr_02666 Neighboring gene STARR-seq mESC enhancer starr_02670 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene laminin, gamma 2 Neighboring gene STARR-seq mESC enhancer starr_02673 Neighboring gene STARR-seq mESC enhancer starr_02677 Neighboring gene laminin, gamma 1 Neighboring gene STARR-seq mESC enhancer starr_02679 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155135069-155135369 Neighboring gene STARR-positive B cell enhancer ABC_E5820 Neighboring gene STARR-positive B cell enhancer ABC_E2568 Neighboring gene predicted pseudogene 8818

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC113818

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nicotinamide-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nicotinamide-nucleotide adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nicotinate-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nicotinate-nucleotide adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nicotinate-nucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein ADP-ribosyltransferase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein ADP-ribosyltransferase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in NAD biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytoplasmic translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
    Names
    NMN adenylyltransferase 2
    NMN/NaMN adenylyltransferase 2
    blad
    naMN adenylyltransferase 1
    naMN adenylyltransferase 2
    nicotinamide mononucleotide adenylyltransferase 2
    nicotinate-nucleotide adenylyltransferase 1
    nicotinate-nucleotide adenylyltransferase 2
    protein bloated bladder
    pyridine nucleotide adenylyltransferase 2
    NP_001405031.1
    NP_001405032.1
    NP_780669.1
    XP_006529519.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418102.1NP_001405031.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099735, AC110038
      UniProtKB/TrEMBL
      A0A087WRE3
    2. NM_001418103.1NP_001405032.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC099735
    3. NM_175460.4NP_780669.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_780669.1

      Status: VALIDATED

      Source sequence(s)
      AC099735, AC110038
      Consensus CDS
      CCDS15368.1
      UniProtKB/Swiss-Prot
      Q8BNJ3
      UniProtKB/TrEMBL
      A0A087WRE3, Q5HZI3
      Related
      ENSMUSP00000041110.9, ENSMUST00000043313.15
      Conserved Domains (1) summary
      cd09286
      Location:9302
      NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic

    RNA

    1. NR_184685.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099735, AC110038
      Related
      ENSMUST00000186368.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      152830532..152995012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529456.4XP_006529519.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A0A087WRE3
      Conserved Domains (1) summary
      cl00015
      Location:9237
      nt_trans; nucleotidyl transferase superfamily

    RNA

    1. XR_387163.4 RNA Sequence