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    Edem3 ER degradation enhancer, mannosidase alpha-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 66967, updated on 9-Dec-2024

    Summary

    Official Symbol
    Edem3provided by MGI
    Official Full Name
    ER degradation enhancer, mannosidase alpha-like 3provided by MGI
    Primary source
    MGI:MGI:1914217
    See related
    Ensembl:ENSMUSG00000043019 AllianceGenome:MGI:1914217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310050N11Rik
    Summary
    Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in ERAD pathway and mannoprotein catabolic process. Acts upstream of or within glycoprotein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.8), adrenal adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Edem3 in Genome Data Viewer
    Location:
    1 G2; 1 64.34 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (151631099..151698079)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (151755344..151822328)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810414N06 gene Neighboring gene STARR-positive B cell enhancer ABC_E8961 Neighboring gene STARR-positive B cell enhancer ABC_E2565 Neighboring gene predicted gene, 41969 Neighboring gene STARR-positive B cell enhancer ABC_E7757 Neighboring gene STARR-positive B cell enhancer ABC_E5818 Neighboring gene STARR-positive B cell enhancer mm9_chr1:153670267-153670567 Neighboring gene STARR-seq mESC enhancer starr_02632 Neighboring gene predicted gene, 53604 Neighboring gene U4 spliceosomal RNA Neighboring gene RIKEN cDNA 1700025G04 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ER degradation-enhancing alpha-mannosidase-like protein 3
    Names
    ER degradation-enhancing alpha-mannosidase-like 3
    alpha-1,2-mannosidase EDEM3
    NP_001034733.2
    NP_001298094.1
    NP_001298095.1
    XP_006529858.1
    XP_006529859.1
    XP_006529860.1
    XP_006529861.1
    XP_011246362.1
    XP_011246363.1
    XP_011246364.1
    XP_011246365.1
    XP_017177572.1
    XP_017177574.1
    XP_030098091.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039644.2NP_001034733.2  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001034733.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB188342, AK009915, AK141326, BC060718
      Consensus CDS
      CCDS35736.1
      UniProtKB/Swiss-Prot
      B2RS10, B9EHZ4, Q2HXL6, Q6P9L0
      UniProtKB/TrEMBL
      B7ZNN9
      Related
      ENSMUSP00000058941.6, ENSMUST00000059498.12
      Conserved Domains (3) summary
      cd02126
      Location:665790
      PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:808897
      DUF4521; Protein of unknown function (DUF4521)
    2. NM_001311165.1NP_001298094.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction and contains an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC112679, AC156542
      Consensus CDS
      CCDS78702.1
      UniProtKB/TrEMBL
      A0A087WQK5, B7ZNN9
      Related
      ENSMUSP00000140234.2, ENSMUST00000191070.2
      Conserved Domains (3) summary
      cd02126
      Location:646771
      PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:794883
      DUF4521; Protein of unknown function (DUF4521)
    3. NM_001311166.1NP_001298095.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001298095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC112679, AC156542
      Consensus CDS
      CCDS78701.1
      UniProtKB/TrEMBL
      B7ZNN9, B7ZNP0
      Related
      ENSMUSP00000140775.2, ENSMUST00000187951.7
      Conserved Domains (3) summary
      cd02126
      Location:647772
      PA_EDEM3_like; PA_EDEM3_like: protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:790879
      DUF4521; Protein of unknown function (DUF4521)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      151631099..151698079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529795.3XP_006529858.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:666791
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:821914
      DUF4521; Protein of unknown function (DUF4521)
    2. XM_006529796.3XP_006529859.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X5

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:666791
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:810903
      DUF4521; Protein of unknown function (DUF4521)
    3. XM_011248061.2XP_011246363.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X3

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:666791
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:820913
      DUF4521; Protein of unknown function (DUF4521)
    4. XM_011248062.2XP_011246364.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X6

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:666791
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:809902
      DUF4521; Protein of unknown function (DUF4521)
    5. XM_006529797.3XP_006529860.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X8

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:666791
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:805898
      DUF4521; Protein of unknown function (DUF4521)
    6. XM_006529798.3XP_006529861.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X9

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:647772
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:802895
      DUF4521; Protein of unknown function (DUF4521)
    7. XM_011248060.3XP_011246362.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A087WR24, B7ZNN9
      Related
      ENSMUSP00000140443.2, ENSMUST00000188145.7
      Conserved Domains (3) summary
      cd02126
      Location:665790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:820913
      DUF4521; Protein of unknown function (DUF4521)
    8. XM_017322083.3XP_017177572.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X4

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:665790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:819912
      DUF4521; Protein of unknown function (DUF4521)
    9. XM_017322085.2XP_017177574.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X7

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:665790
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:808901
      DUF4521; Protein of unknown function (DUF4521)
    10. XM_011248063.2XP_011246365.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X10

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:646771
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:801894
      DUF4521; Protein of unknown function (DUF4521)
    11. XM_030242231.2XP_030098091.1  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X11

      UniProtKB/TrEMBL
      B7ZNN9
      Conserved Domains (3) summary
      cd02126
      Location:646771
      PA_EDEM3_like; protease associated domain (PA) domain-containing EDEM3-like proteins. This group contains various PA domain-containing proteins similar to mouse EDEM3 (ER-degradation-enhancing mannosidase-like 3 protein). EDEM3 contains a region, similar to Class I ...
      pfam01532
      Location:60499
      Glyco_hydro_47; Glycosyl hydrolase family 47
      pfam15021
      Location:785878
      DUF4521; Protein of unknown function (DUF4521)