Coq7 coenzyme Q7, hydroxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Coq7provided by RGD
Official Full Name: coenzyme Q7, hydroxylaseprovided by RGD
Primary source: RGD:2381
See related: EnsemblRapid:ENSRNOG00000017012 AllianceGenome:RGD:2381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 3-demethoxyubiquinol 3-hydroxylase activity and chromatin binding activity. Involved in response to xenobiotic stimulus and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrial inner membrane and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 9 and primary coenzyme Q10 deficiency 8. Orthologous to human COQ7 (coenzyme Q7, hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 253.4), Muscle (RPKM 136.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (182270570..182285959, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (172836359..172851173, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (188176060..188190874, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

groEL gene encodes a protein of 60 kDa with a high degree of homology (99% similarity) to those of other leptospiral serovar
Title: Cloning, expression, and homology modeling of GroEL protein from Leptospira interrogans serovar autumnalis strain N2.
In proteomic study of left ventricular hypertrophy, three altered protein spots corresponded to two unique proteins that were identified as Calsarcin-1 (CS-1) and ubiquinone biosynthesis protein COQ7 homolog.
Title: Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134107 (e-PCR)
- UniSTS:217389

AU027868 (e-PCR)
- UniSTS:112886

BF387931 (e-PCR)
- UniSTS:244474

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-demethoxyubiquinol 3-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-demethoxyubiquinol 3-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of adult lifespan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of reactive oxygen species metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory electron transport chain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquinone biosynthesis complex	IEA Inferred from Electronic Annotation more info
part_of ubiquinone biosynthesis complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5-demethoxyubiquinone hydroxylase, mitochondrial

Names: Coenzyme q (ubiquinone) biosynthetic enzyme (DHPB methyltransferase) 7; DMQ hydroxylase; coenzyme Q biosynthesis protein 7 homolog; coenzyme Q7 homolog, ubiquinone; demethyl-Q 7; timing protein clk-1 homolog; ubiquinone biosynthesis monooxygenase COQ7; ubiquinone biosynthesis protein COQ7 homolog

NP_036917.2

EC 1.14.99.60

XP_006230170.1

EC 1.14.99.60

XP_038957455.1

EC 1.14.99.60

XP_063137596.1

EC 1.14.99.60

XP_063137598.1

EC 1.14.99.60

XP_063137603.1

EC 1.14.99.60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012785.3 → NP_036917.2 5-demethoxyubiquinone hydroxylase, mitochondrial

See identical proteins and their annotated locations for NP_036917.2

Status: VALIDATED

Source sequence(s)

AI711299, BF558335, FQ225865

UniProtKB/Swiss-Prot

O08887, Q63619

UniProtKB/TrEMBL

A6I8H3, G3V879

Conserved Domains (1) summary

pfam03232
Location:49 → 216

COQ7; Ubiquinone biosynthesis protein COQ7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

182270570..182285959 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281528.1 → XP_063137598.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform X2
XM_063281526.1 → XP_063137596.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform X1
XM_006230108.4 → XP_006230170.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform X3

See identical proteins and their annotated locations for XP_006230170.1

UniProtKB/TrEMBL

A6I8H4

Related

ENSRNOP00000022988.7, ENSRNOT00000022988.7

Conserved Domains (1) summary

pfam03232
Location:69 → 236

COQ7; Ubiquinone biosynthesis protein COQ7
XM_063281533.1 → XP_063137603.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform X4
XM_039101527.2 → XP_038957455.1 5-demethoxyubiquinone hydroxylase, mitochondrial isoform X5

Conserved Domains (1) summary

cl00264
Location:69 → 104

Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins