Rasd2 RASD family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasd2provided by MGI
Official Full Name: RASD family, member 2provided by MGI
Primary source: MGI:MGI:1922391
See related: Ensembl:ENSMUSG00000034472 AllianceGenome:MGI:1922391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rhes; TEM2; TEM-2; 4930526B11Rik
Summary: Predicted to enable several functions, including G-protein beta-subunit binding activity; GTP binding activity; and ubiquitin conjugating enzyme binding activity. Involved in dopaminergic synaptic transmission and locomotory behavior. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; inner ear; lung; telencephalon; and thyroid gland. Orthologous to human RASD2 (RASD family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 15.5), frontal lobe adult (RPKM 12.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C1; 8 35.61 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (75940572..75950741)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (75213944..75224113)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like Effects via Dopamine D2 Receptor Activation in Ovariectomized Mice.
Title: Rasd2 Mediates Acute Fasting-Induced Antidepressant-Like Effects via Dopamine D2 Receptor Activation in Ovariectomized Mice.
The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses.
Title: The striatal-enriched protein Rhes is a critical modulator of cocaine-induced molecular and behavioral responses.
Rhes is a major regulator of mitophagy via Nix, which may determine striatal vulnerability in the brain
Title: Rhes, a striatal-enriched protein, promotes mitophagy via Nix.
guanine nucleotide exchange factor RasGRP1 inhibited Rhes-mediated control of striatal motor activity in mice. RasGRP1 stabilized Rhes, increasing its synaptic accumulation in the striatum.
Title: RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
that Rasd2 mutants display deficits in basal prepulse inhibition that, in turn, exacerbate gating disruption under psychotomimetic drug challenge
Title: Rasd2 Modulates Prefronto-Striatal Phenotypes in Humans and 'Schizophrenia-Like Behaviors' in Mice.
Study showed that both genetic deletion of Rhes and pharmacological blockade of mTORC1 significantly attenuate dyskinesia development by reducing the sensitization of striato-nigral medium-sized spiny neurons to levodopa
Title: Genetic deletion of Rhes or pharmacological blockade of mTORC1 prevent striato-nigral neurons activation in levodopa-induced dyskinesia.
ectopic expression of Rhes in the cerebellum of N171-82Q mice, during the asymptomatic period led to an exacerbation of motor deficits, including loss of balance and motor incoordination with ataxia-like features
Title: Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion
Title: Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion.
Brain Rhes expression is decreased in a mouse model of Huntington's disease.
Title: Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.
Rhes robustly binds the autophagy regulator Beclin-1, decreasing its inhibitory interaction with Bcl-2 independent of JNK-1 signaling.
Title: Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein beta-subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in locomotory behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP-binding protein Rhes

Names: ras homolog enriched in striatum

NP_083458.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029182.2 → NP_083458.1 GTP-binding protein Rhes

See identical proteins and their annotated locations for NP_083458.1

Status: VALIDATED

Source sequence(s)

AC076974

Consensus CDS

CCDS52602.1

UniProtKB/Swiss-Prot

P63032, Q9WVD3

UniProtKB/TrEMBL

Q8JZW1

Related

ENSMUSP00000118070.2, ENSMUST00000139848.8

Conserved Domains (1) summary

cd04143
Location:20 → 266

Rhes_like; Ras homolog enriched in striatum (Rhes) and activator of G-protein signaling 1 (Dexras1/AGS1)