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    Apobec4 apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 71281, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Apobec4provided by MGI
    Official Full Name
    apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 4provided by MGI
    Primary source
    MGI:MGI:1918531
    See related
    Ensembl:ENSMUSG00000055547 AllianceGenome:MGI:1918531
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933431M11Rik
    Summary
    Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be involved in mRNA processing. Orthologous to human APOBEC4 (apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 23.3) See more
    Orthologs
    human all
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    Genomic context

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    See Apobec4 in Genome Data Viewer
    Location:
    1 G3; 1 65.01 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152626302..152633295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152750551..152757544)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ral guanine nucleotide dissociation stimulator,-like 1 Neighboring gene predicted gene, 51749 Neighboring gene STARR-seq mESC enhancer starr_02640 Neighboring gene STARR-seq mESC enhancer starr_02641 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5819 Neighboring gene STARR-positive B cell enhancer ABC_E2566 Neighboring gene STARR-positive B cell enhancer ABC_E2567 Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene STARR-positive B cell enhancer ABC_E1566 Neighboring gene STARR-positive B cell enhancer ABC_E4358 Neighboring gene STARR-seq mESC enhancer starr_02648 Neighboring gene neutrophil cytosolic factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. Rogozin IB, et al. Cell Cycle, 2005 Sep. PMID 16082223
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APOBEC4 is expressed primarily in testis which suggests the possibility that it is an editing enzyme for mRNAs involved in spermatogenesis
      Title: APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    putative C->U-editing enzyme APOBEC-4
    Names
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
    NP_001074666.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081197.1 → NP_001074666.1  putative C->U-editing enzyme APOBEC-4

      See identical proteins and their annotated locations for NP_001074666.1

      Status: PROVISIONAL

      Source sequence(s)
      AC123613
      Consensus CDS
      CCDS35738.1
      UniProtKB/Swiss-Prot
      Q497M3
      Related
      ENSMUSP00000069723.5, ENSMUST00000068875.5
      Conserved Domains (2) summary
      pfam08210
      Location:47 → 203
      APOBEC_N; APOBEC-like N-terminal domain
      cl21470
      Location:192 → 255
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      152626302..152633295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q497M3.2 GenPept UniProtKB/Swiss-Prot:Q497M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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