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    Serbp1 serpine1 mRNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66870, updated on 4-Jan-2025

    Summary

    Official Symbol
    Serbp1provided by MGI
    Official Full Name
    serpine1 mRNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1914120
    See related
    Ensembl:ENSMUSG00000036371 AllianceGenome:MGI:1914120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pairbp1; 1200009K13Rik; 9330147J08Rik
    Summary
    Enables ribosome binding activity; translation elongation factor binding activity; and translation repressor activity. Involved in ribosome hibernation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex; early conceptus; and ovary. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 69.9), liver E14 (RPKM 49.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Serbp1 in Genome Data Viewer
    Location:
    6 C1; 6 30.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67243963..67266286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67266979..67289302)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16173 Neighboring gene predicted gene, 38825 Neighboring gene STARR-seq mESC enhancer starr_16175 Neighboring gene Sod1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16176 Neighboring gene STARR-seq mESC enhancer starr_16180 Neighboring gene STARR-positive B cell enhancer ABC_E2787 Neighboring gene STARR-seq mESC enhancer starr_16184 Neighboring gene interleukin 12 receptor, beta 2 Neighboring gene predicted gene, 57761 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding  
    enables SUMO binding  
    enables SUMO binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables ribosome binding PubMed 
    enables ribosome binding  
    enables ribosome binding  
    enables translation elongation factor binding PubMed 
    enables translation repressor activity PubMed 
    enables translation repressor activity  
    enables translation repressor activity  
    Process Evidence Code Pubs
    involved_in PML body organization  
    involved_in PML body organization  
    involved_in negative regulation of translation PubMed 
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in regulation of apoptotic process  
    involved_in ribosome hibernation PubMed 
    involved_in ribosome hibernation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in membraneless organelle  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    SERPINE1 mRNA-binding protein 1
    Names
    PAI-1 mRNA-binding protein
    PAI-RBP1
    PAI1 RNA-binding protein 1
    plasminogen activator inhibitor 1 RNA-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113564.1NP_001107036.1  SERPINE1 mRNA-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001107036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC130822, AK144764, BY083551
      Consensus CDS
      CCDS85061.1
      UniProtKB/TrEMBL
      Q3UMP4, Q3V274
      Related
      ENSMUSP00000144713.2, ENSMUST00000203436.3
      Conserved Domains (2) summary
      pfam04774
      Location:189306
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5119
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    2. NM_001113565.1NP_001107037.1  SERPINE1 mRNA-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001107037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC130822, AK004678, AK010860
      Consensus CDS
      CCDS85060.1
      UniProtKB/TrEMBL
      Q3UJK2
      Related
      ENSMUSP00000144913.2, ENSMUST00000203077.3
      Conserved Domains (2) summary
      pfam04774
      Location:189297
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5119
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    3. NM_001113566.1NP_001107038.1  SERPINE1 mRNA-binding protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001107038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AC130822, BC030502, BY083551
      Consensus CDS
      CCDS85062.1
      UniProtKB/TrEMBL
      Q3UEI6, Q3V274
      Related
      ENSMUSP00000145472.2, ENSMUST00000204293.3
      Conserved Domains (2) summary
      pfam04774
      Location:189291
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
    4. NM_025814.2NP_080090.2  SERPINE1 mRNA-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080090.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC130822, AK004678
      Consensus CDS
      CCDS20219.1
      UniProtKB/Swiss-Prot
      Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9CY58, Q9DBY6
      UniProtKB/TrEMBL
      Q3UJK2
      Related
      ENSMUSP00000039110.5, ENSMUST00000042990.7
      Conserved Domains (2) summary
      pfam04774
      Location:189312
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5119
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      67243963..67266286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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