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    Racgap1 Rac GTPase-activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 26934, updated on 13-Jan-2025

    Summary

    Official Symbol
    Racgap1provided by MGI
    Official Full Name
    Rac GTPase-activating protein 1provided by MGI
    Primary source
    MGI:MGI:1349423
    See related
    Ensembl:ENSMUSG00000023015 AllianceGenome:MGI:1349423
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gtl11; Band25; GTPase; MgcRacGAP; mKIAA1478
    Summary
    Predicted to enable several functions, including GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and tubulin binding activity. Involved in neuroblast proliferation and regulation of embryonic development. Predicted to be located in cytoplasmic side of plasma membrane; mitotic spindle; and nucleoplasm. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and nose. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 49.5), liver E14 (RPKM 31.3) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Racgap1 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99518377..99549504, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99620496..99651656, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34765 Neighboring gene aquaporin 5 Neighboring gene aquaporin 6 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99481947-99482248 Neighboring gene predicted gene, 34880 Neighboring gene acid-sensing ion channel 1 Neighboring gene STARR-seq mESC enhancer starr_39720

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables gamma-tubulin binding  
    enables gamma-tubulin binding  
    enables metal ion binding  
    enables microtubule binding  
    enables microtubule binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    involved_in actomyosin contractile ring assembly  
    involved_in actomyosin contractile ring assembly  
    involved_in erythrocyte differentiation  
    involved_in erythrocyte differentiation  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic cytokinesis  
    involved_in mitotic spindle midzone assembly  
    involved_in mitotic spindle midzone assembly  
    involved_in mitotic spindle midzone assembly  
    involved_in monoatomic ion transport  
    involved_in neuroblast proliferation PubMed 
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of attachment of spindle microtubules to kinetochore  
    involved_in regulation of embryonic development PubMed 
    involved_in signal transduction  
    involved_in spermatogenesis  
    involved_in sulfate transmembrane transport  
    involved_in sulfate transmembrane transport  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in Flemming body  
    located_in acrosomal vesicle  
    part_of centralspindlin complex  
    part_of centralspindlin complex  
    part_of centralspindlin complex  
    is_active_in cleavage furrow  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    is_active_in midbody  
    located_in midbody  
    located_in midbody  
    located_in mitotic spindle  
    located_in mitotic spindle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in spindle  
    is_active_in spindle midzone  
    located_in spindle midzone  
    located_in spindle midzone  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    rac GTPase-activating protein 1
    Names
    male germ cell RacGap

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253808.2NP_001240737.1  rac GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_001240737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC139317
      Consensus CDS
      CCDS27825.1
      UniProtKB/Swiss-Prot
      Q3THR5, Q3TI41, Q3TM81, Q9WVM1
      Related
      ENSMUSP00000023756.6, ENSMUST00000023756.12
      Conserved Domains (3) summary
      cd04382
      Location:347540
      RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
      pfam00261
      Location:43108
      Tropomyosin
      cd20821
      Location:286339
      C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
    2. NM_001253809.2NP_001240738.1  rac GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_001240738.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC139317
      Consensus CDS
      CCDS27825.1
      UniProtKB/Swiss-Prot
      Q3THR5, Q3TI41, Q3TM81, Q9WVM1
      Conserved Domains (3) summary
      cd04382
      Location:347540
      RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
      pfam00261
      Location:43108
      Tropomyosin
      cd20821
      Location:286339
      C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
    3. NM_001411865.1NP_001398794.1  rac GTPase-activating protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC139317
      UniProtKB/Swiss-Prot
      Q3THR5, Q3TI41, Q3TM81, Q9WVM1
    4. NM_001411866.1NP_001398795.1  rac GTPase-activating protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC139317
      UniProtKB/Swiss-Prot
      Q3THR5, Q3TI41, Q3TM81, Q9WVM1
    5. NM_012025.8NP_036155.1  rac GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_036155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC139317
      Consensus CDS
      CCDS27825.1
      UniProtKB/Swiss-Prot
      Q3THR5, Q3TI41, Q3TM81, Q9WVM1
      Related
      ENSMUSP00000126417.2, ENSMUST00000171702.8
      Conserved Domains (3) summary
      cd04382
      Location:347540
      RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...
      pfam00261
      Location:43108
      Tropomyosin
      cd20821
      Location:286339
      C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins

    RNA

    1. NR_177956.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139317
    2. NR_177957.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139317
    3. NR_177958.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139317
    4. NR_177959.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC139317

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99518377..99549504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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