Anxa6 annexin A6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa6provided by MGI
Official Full Name: annexin A6provided by MGI
Primary source: MGI:MGI:88255
See related: Ensembl:ENSMUSG00000018340 AllianceGenome:MGI:88255
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Anx6; Cabm; Camb; AnxVI
Summary: Predicted to enable several functions, including GTP binding activity; cholesterol binding activity; and phospholipid binding activity. Involved in apoptotic signaling pathway and mitochondrial calcium ion homeostasis. Acts upstream of or within calcium ion transport and regulation of muscle contraction. Located in perinuclear region of cytoplasm. Is expressed in lung; meninges; primary palate; vascular system; and yolk sac blood vessel. Orthologous to human ANXA6 (annexin A6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 129.0), limb E14.5 (RPKM 86.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54869779..54924297, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54978953..55033471, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity.
Title: Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity.
A conserved annexin A6-mediated membrane repair mechanism in muscle, heart, and nerve.
Title: A conserved annexin A6-mediated membrane repair mechanism in muscle, heart, and nerve.
Annexin A6 Is Critical to Maintain Glucose Homeostasis and Survival During Liver Regeneration in Mice.
Title: Annexin A6 Is Critical to Maintain Glucose Homeostasis and Survival During Liver Regeneration in Mice.
Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein-Deficient Mice.
Title: Lack of Annexin A6 Exacerbates Liver Dysfunction and Reduces Lifespan of Niemann-Pick Type C Protein-Deficient Mice.
annexin overexpression promoted external blebs enriched in Ca2+ and correlated with a reduction of intracellular Ca2+ at the injury site. Annexin A6 overexpression reduced membrane injury, consistent with enhanced repair. Treatment with recombinant annexin A6 protected against acute muscle injury in vitro and in vivo.
Title: Recombinant annexin A6 promotes membrane repair and protects against muscle injury.
Annexin A6-deficient mice showed increased sensitivity to mechanical stimuli, overexpression of annexin A6 in sensory neurons attenuated mechanical pain in a mouse model of osteoarthritis
Title: Inhibition of somatosensory mechanotransduction by annexin A6.
AnxA6 contributing to the fine-tuning of hepatic glucose metabolism with potential consequences for the systemic control of glucose in health and disease.
Title: Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet.
Findings define a novel role for AnxA6 in articular chondrocytes via its modulation of Wnt/beta-catenin and NF- kappaB signaling activities and the cross-talk between these two signaling pathways.
Title: Annexin A6 regulates catabolic events in articular chondrocytes via the modulation of NF-κB and Wnt/ß-catenin signaling.
AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.
Title: Annexin A6 regulates interleukin-2-mediated T-cell proliferation.
AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release.
Title: Annexin A6 regulates adipocyte lipid storage and adiponectin release.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Spontaneous (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X13460 (e-PCR)
- UniSTS:163501

AW107198 (e-PCR)
- UniSTS:180202

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of sequestering of calcium ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A6

Names: 67 kDa calelectrin; CPB-II; annexin VI, p68; annexin-6; calphobindin-II; chromobindin-20; lipocortin VI; p68; p70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110211.2 → NP_001103681.1 annexin A6 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AK146509, AK147066, AK160754, BB033332, BY316619

Consensus CDS

CCDS48799.1

UniProtKB/TrEMBL

F8WIT2, Q3TUI1

Related

ENSMUSP00000099788.3, ENSMUST00000102727.3

Conserved Domains (2) summary

smart00335
Location:538 → 587

ANX; Annexin repeats

pfam00191
Location:439 → 504

Annexin; Annexin
NM_013472.5 → NP_038500.2 annexin A6 isoform a

See identical proteins and their annotated locations for NP_038500.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AK146509, AK147066, BB033332, BY316619

Consensus CDS

CCDS24705.1

UniProtKB/Swiss-Prot

P14824, Q8BSS4

UniProtKB/TrEMBL

Q3UI56

Related

ENSMUSP00000104511.4, ENSMUST00000108883.10

Conserved Domains (1) summary

pfam00191
Location:439 → 504

Annexin; Annexin

RNA

NR_138556.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL593846