Srsf3 serine and arginine rich splicing factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srsf3provided by RGD
Official Full Name: serine and arginine rich splicing factor 3provided by RGD
Primary source: RGD:1309233
See related: EnsemblRapid:ENSRNOG00000000520 AllianceGenome:RGD:1309233
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sfrs3
Summary: Enables sequence-specific mRNA binding activity. Predicted to be involved in mRNA export from nucleus; primary miRNA processing; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus. Predicted to be active in nuclear speck. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 933.5), Spleen (RPKM 600.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (7093529..7103517)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (7091928..7101860)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (6288285..6298218)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver
Title: Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-L10838 (e-PCR)
- UniSTS:3193

BE117632 (e-PCR)
- UniSTS:248702

RH130376 (e-PCR)
- UniSTS:213660

SFRS3_1875 (e-PCR)
- UniSTS:280994

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info
NOT enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables primary miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein-RNA sequence-specific adaptor activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in mRNA cis splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 3

Names: splicing factor, arginine/serine-rich 3 (SRp20)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047907.4 → NP_001041372.1 serine/arginine-rich splicing factor 3

See identical proteins and their annotated locations for NP_001041372.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

Q0ZFS8

Related

ENSRNOP00000085609.2, ENSRNOT00000117194.2

Conserved Domains (1) summary

cd12645
Location:6 → 86

RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)