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    Tifa TRAF-interacting protein with forkhead-associated domain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tifaprovided by RGD
    Official Full Name
    TRAF-interacting protein with forkhead-associated domainprovided by RGD
    Primary source
    RGD:1359151
    See related
    EnsemblRapid:ENSRNOG00000010941 AllianceGenome:RGD:1359151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    T2bp; Ab2-389
    Summary
    Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein homooligomerization; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 137.4), Lung (RPKM 50.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tifa in Genome Data Viewer
    Location:
    2q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218927724..218942111)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (216257926..216267635)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (232104394..232137425)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alpha-kinase 1 Neighboring gene ribosomal protein L29, pseudogene 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 2 Neighboring gene adaptor-related protein complex 1 associated regulatory protein Neighboring gene transfer RNA alanine (anticodon AGC) 70 Neighboring gene family with sequence similarity 241 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Gaudet RG, et al. Science, 2015 Jun 12. PMID 26068852
    2. ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System. Zimmermann S, et al. Cell Rep, 2017 Sep 5. PMID 28877472
    3. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. Milivojevic M, et al. PLoS Pathog, 2017 Feb. PMID 28222186, Free PMC Article
    4. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation. Huang CC, et al. Mol Cell Biol, 2012 Jul. PMID 22566686, Free PMC Article
    5. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Zhou P, et al. Nature, 2018 Sep. PMID 30111836

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic pattern recognition receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    TRAF-interacting protein with FHA domain-containing protein A
    Names
    TRAF2-binding protein
    Traf2 binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014044.1 → NP_001014066.1  TRAF-interacting protein with FHA domain-containing protein A

      See identical proteins and their annotated locations for NP_001014066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083765
      UniProtKB/Swiss-Prot
      Q5XIB9
      UniProtKB/TrEMBL
      A6HVM2
      Related
      ENSRNOP00000061870.1, ENSRNOT00000014533.8
      Conserved Domains (1) summary
      cd00060
      Location:47 → 129
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      218927724..218942111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102464.2 → XP_038958392.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

      UniProtKB/Swiss-Prot
      Q5XIB9
      UniProtKB/TrEMBL
      A6HVM2
      Conserved Domains (1) summary
      cd00060
      Location:47 → 129
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    2. XM_039102463.2 → XP_038958391.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

      UniProtKB/Swiss-Prot
      Q5XIB9
      UniProtKB/TrEMBL
      A6HVM2
      Related
      ENSRNOP00000105247.1, ENSRNOT00000151568.1
      Conserved Domains (1) summary
      cd00060
      Location:47 → 129
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    3. XM_039102465.2 → XP_038958393.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

      UniProtKB/Swiss-Prot
      Q5XIB9
      UniProtKB/TrEMBL
      A6HVM2
      Related
      ENSRNOP00000077082.1, ENSRNOT00000112612.2
      Conserved Domains (1) summary
      cd00060
      Location:47 → 129
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

    RNA

    1. XR_010063617.1 RNA Sequence

    2. XR_010063618.1 RNA Sequence

    3. XR_005500306.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIB9.1 GenPept UniProtKB/Swiss-Prot:Q5XIB9

    Gene LinkOut

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