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    Lrrc8b leucine rich repeat containing 8 VRAC subunit B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305135, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc8bprovided by RGD
    Official Full Name
    leucine rich repeat containing 8 VRAC subunit Bprovided by RGD
    Primary source
    RGD:1563429
    See related
    EnsemblRapid:ENSRNOG00000002129 AllianceGenome:RGD:1563429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563429
    Summary
    Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in several processes, including aspartate transmembrane transport; cyclic-GMP-AMP transmembrane import across plasma membrane; and monoatomic anion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8B (leucine rich repeat containing 8 VRAC subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 152.7), Kidney (RPKM 151.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc8b in Genome Data Viewer
    Location:
    14p22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (4655273..4721648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (4350462..4416336, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (5414872..5482004, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 8 VRAC subunit C Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene uncharacterized LOC108352696 Neighboring gene uncharacterized LOC108352839 Neighboring gene uncharacterized LOC134481817 Neighboring gene ATP-binding cassette, subfamily G (WHITE), member 3-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels. Lutter D, et al. J Cell Sci, 2017 Mar 15. PMID 28193731
    2. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Voss FK, et al. Science, 2014 May 9. PMID 24790029
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables volume-sensitive anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of monoatomic ion channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    volume-regulated anion channel subunit LRRC8B
    Names
    leucine rich repeat containing 8 family, member B
    leucine-rich repeat-containing protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107204.3 → NP_001100674.1  volume-regulated anion channel subunit LRRC8B

      See identical proteins and their annotated locations for NP_001100674.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6K5Q4, D4A758
      Related
      ENSRNOP00000002897.4, ENSRNOT00000002897.8
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 792
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      4655273..4721648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273044.1 → XP_063129114.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/TrEMBL
      A6K5Q4, D4A758

    2. XM_039091815.2 → XP_038947743.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/TrEMBL
      A6K5Q4, D4A758
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 792
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    3. XM_039091813.2 → XP_038947741.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/TrEMBL
      A6K5Q4, D4A758
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 792
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    4. XM_039091812.2 → XP_038947740.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/TrEMBL
      A6K5Q4, D4A758
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 792
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8

    5. XM_039091814.2 → XP_038947742.1  volume-regulated anion channel subunit LRRC8B isoform X1

      UniProtKB/TrEMBL
      A6K5Q4, D4A758
      Conserved Domains (4) summary
      PLN00113
      Location:428 → 692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578 → 792
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465 → 488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 334
      Pannexin_like; Pannexin-like TM region of LRRC8
    Nucleotide Protein Strain
    Heading Accession and Version

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