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    Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300027, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpihbp1provided by RGD
    Official Full Name
    glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1provided by RGD
    Primary source
    RGD:1564237
    See related
    EnsemblRapid:ENSRNOG00000064680 AllianceGenome:RGD:1564237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564237
    Summary
    Predicted to enable several functions, including lipase binding activity; lipoprotein lipase activator activity; and lipoprotein particle binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of chylomicron remnant clearance; and protein transport. Predicted to act upstream of or within lipid transport. Predicted to be located in apical plasma membrane; basolateral plasma membrane; and external side of plasma membrane. Predicted to be part of catalytic complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in familial GPIHBP1 deficiency. Orthologous to human GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 84.8), Lung (RPKM 77.7) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gpihbp1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109166334..109169448)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107285584..107288702)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (116632496..116635543)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member L Neighboring gene lymphocyte antigen 6 family member H Neighboring gene zinc finger protein 41 Neighboring gene GLI family zinc finger 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chylomicron binding  
    enables chylomicron binding  
    enables high-density lipoprotein particle binding  
    enables lipase binding  
    enables lipase binding  
    enables lipoprotein lipase activator activity  
    enables lipoprotein particle binding  
    enables protein transporter activity  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis  
    NOT acts_upstream_of_or_within cholesterol transport  
    involved_in intracellular protein transport  
    acts_upstream_of_or_within lipid transport  
    involved_in positive regulation of chylomicron remnant clearance  
    involved_in positive regulation of lipoprotein lipase activity  
    involved_in protein import  
    involved_in protein localization to cell surface  
    involved_in protein stabilization  
    involved_in response to heparin  
    involved_in transcytosis  
    involved_in triglyceride catabolic process  
    involved_in triglyceride homeostasis  
    involved_in triglyceride homeostasis  
    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    part_of catalytic complex  
    located_in cell surface  
    located_in external side of plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
    Names
    GPI-anchored HDL-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130547.1NP_001124019.1  glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 precursor

      See identical proteins and their annotated locations for NP_001124019.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HS12, D3ZZL5
      Related
      ENSRNOP00000093917.1, ENSRNOT00000103232.2
      Conserved Domains (1) summary
      cd00117
      Location:69146
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      109166334..109169448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078806.2XP_038934734.1  glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A6HS11
      Conserved Domains (1) summary
      cl10471
      Location:69102
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
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