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    Slc29a4 solute carrier family 29 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc29a4provided by RGD
    Official Full Name
    solute carrier family 29 member 4provided by RGD
    Primary source
    RGD:1310545
    See related
    EnsemblRapid:ENSRNOG00000001115 AllianceGenome:RGD:1310545
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables monoamine transmembrane transporter activity. Involved in monoamine transport. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 18.5), Adrenal (RPKM 15.2) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc29a4 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16967047..16998276, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11853540..11884660, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13914114..13924511, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352424 Neighboring gene trinucleotide repeat containing 18 Neighboring gene uncharacterized LOC120095837 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene monocyte to macrophage differentiation-associated 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4). Usui T, et al. J Neurochem, 2016 Nov. PMID 27501284
    2. Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. Okura T, et al. J Pharm Sci, 2011 Sep. PMID 21538354
    3. Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxins. Wu KC, et al. J Neurochem, 2015 Dec. PMID 26376205
    4. Metformin pathways: pharmacokinetics and pharmacodynamics. Gong L, et al. Pharmacogenet Genomics, 2012 Nov. PMID 22722338, Free PMC Article
    5. Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. Duan H, et al. J Pharmacol Exp Ther, 2010 Dec. PMID 20858707, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest the elimination of histamine from the CSF via plasma membrane monoamine transporter at the blood-brain barrier and blood-CSF barrier
      Title: Histamine elimination from the cerebrospinal fluid across the blood-cerebrospinal fluid barrier: involvement of plasma membrane monoamine transporter (PMAT/SLC29A4).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoamine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenosine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epinephrine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histamine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in norepinephrine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serotonin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    equilibrative nucleoside transporter 4
    Names
    solute carrier family 29 (equilibrative nucleoside transporter), member 4
    solute carrier family 29 (nucleoside transporters), member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105911.1 → NP_001099381.1  equilibrative nucleoside transporter 4

      See identical proteins and their annotated locations for NP_001099381.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474012
      UniProtKB/TrEMBL
      A6K1P5
      Conserved Domains (1) summary
      cl15430
      Location:73 → 495
      Nucleoside_tran; Nucleoside transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16967047..16998276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089186.2 → XP_038945114.1  equilibrative nucleoside transporter 4 isoform X1

      UniProtKB/TrEMBL
      F1M2Y4
      Conserved Domains (1) summary
      cl15430
      Location:73 → 496
      Nucleoside_tran; Nucleoside transporter

    2. XM_039089185.2 → XP_038945113.1  equilibrative nucleoside transporter 4 isoform X1

      UniProtKB/TrEMBL
      F1M2Y4
      Related
      ENSRNOP00000001477.6, ENSRNOT00000001477.7
      Conserved Domains (1) summary
      cl15430
      Location:73 → 496
      Nucleoside_tran; Nucleoside transporter

    3. XM_039089187.2 → XP_038945115.1  equilibrative nucleoside transporter 4 isoform X2

      Conserved Domains (1) summary
      cl15430
      Location:29 → 343
      Nucleoside_tran; Nucleoside transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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