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    Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287631, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wfikkn2provided by RGD
    Official Full Name
    WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2provided by RGD
    Primary source
    RGD:1305361
    See related
    EnsemblRapid:ENSRNOG00000002831 AllianceGenome:RGD:1305361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305361
    Summary
    Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within muscle cell development; roof of mouth development; and skeletal system development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human WFIKKN2 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 217.0), Thymus (RPKM 21.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wfikkn2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79682459..79688553, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (79185563..79191657, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81936156..81943142, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555690 Neighboring gene transducer of ErbB-2.1 Neighboring gene ANKRD40 C-terminal like Neighboring gene LUC7-like 3 pre-mRNA splicing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Hill JJ, et al. Mol Endocrinol, 2003 Jun. PMID 12595574
    2. WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity. Szláma G, et al. FEBS J, 2010 Dec. PMID 21054789
    3. Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Lee YS, et al. Proc Natl Acad Sci U S A, 2013 Sep 24. PMID 24019467, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398592.1 → NP_001385521.1  WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HI39, D3Z9K5
      Related
      ENSRNOP00000003784.5, ENSRNOT00000003784.9
      Conserved Domains (5) summary
      cd00104
      Location:133 → 169
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      cd03575
      Location:450 → 558
      NTR_WFIKKN; NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein ...
      pfam00014
      Location:380 → 431
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam00095
      Location:37 → 86
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'
      cd05765
      Location:205 → 299
      IgI_3_WFIKKN-like; Third immunoglobulin-like domain of the human WFIKKN (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein), and similar domains; member of the I-set of Ig superfamily (IgSF) domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      79682459..79688553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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