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    Bbc3 Bcl-2 binding component 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317673, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bbc3provided by RGD
    Official Full Name
    Bcl-2 binding component 3provided by RGD
    Primary source
    RGD:631434
    See related
    EnsemblRapid:ENSRNOG00000062473 AllianceGenome:RGD:631434
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Puma
    Summary
    Predicted to enable ATPase binding activity. Involved in positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in lysosome. Predicted to be active in mitochondrion. Biomarker of intermittent claudication and transient cerebral ischemia. Orthologous to human BBC3 (BCL2 binding component 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 26.3), Liver (RPKM 22.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bbc3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86141450..86150666)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (77013281..77022509)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78261491..78267802)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene complement C5a receptor 1 Neighboring gene InaF-motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene SUMO1 activating enzyme subunit 1 Neighboring gene ferritin light chain 1, pseudogene 12 Neighboring gene zinc finger CCCH-type containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in determination of adult lifespan IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in execution phase of apoptosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of lymphocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of establishment of protein localization to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of lymphocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of thymocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bcl-2-binding component 3
    Names
    p53 up-regulated modulator of apoptosis

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173837.2NP_776209.1  bcl-2-binding component 3

      See identical proteins and their annotated locations for NP_776209.1

      Status: PROVISIONAL

      Source sequence(s)
      AY157758
      UniProtKB/Swiss-Prot
      Q80ZG6
      UniProtKB/TrEMBL
      A6J8A5
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      86141450..86150666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080914.2XP_038936842.1  bcl-2-binding component 3 isoform X1

    2. XM_039080925.2XP_038936853.1  bcl-2-binding component 3 isoform X3

      UniProtKB/Swiss-Prot
      Q80ZG6
      UniProtKB/TrEMBL
      A6J8A5
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    3. XM_039080919.2XP_038936847.1  bcl-2-binding component 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHA0
      Related
      ENSRNOP00000092134.1, ENSRNOT00000096062.2
      Conserved Domains (1) summary
      pfam15826
      Location:18209
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis