Dgke diacylglycerol kinase epsilon [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dgkeprovided by RGD
Official Full Name: diacylglycerol kinase epsilonprovided by RGD
Primary source: RGD:1560914
See related: EnsemblRapid:ENSRNOG00000002338 AllianceGenome:RGD:1560914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and modulation of chemical synaptic transmission. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in glutamatergic synapse and membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 68.5), Heart (RPKM 58.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (74348931..74374509, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (73853030..73877334, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (76375981..76408224, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that DGKepsilon plays an important role in neuronal and brain functions through its distinct neuronal expression and subcellular localization and also through coordinated arrangement with other molecules involving the phosphoinositide signaling pathway
Title: Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells.
The DGKepsilon is evident in the outer limiting membrane.
Title: Distinct expression and localization of diacylglycerol kinase isozymes in rat retina.
Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
Title: Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.
DGKepsilon interacts with actin stress fibers and is involved in their stability in vascular smooth muscle cells.
Title: Localization of diacylglycerol kinase epsilon on stress fibers in vascular smooth muscle cells.

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General gene information

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Markers

RH140021 (e-PCR)
- UniSTS:222103

Dgke (e-PCR), detects polymorphism
- UniSTS:546733

RH144207 (e-PCR)
- UniSTS:233452

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerolipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diacylglycerol kinase epsilon

Names: diacylglycerol kinase, epsilon 64kDa

NP_001381287.1

EC 2.7.1.107

NP_001381288.1

EC 2.7.1.107

XP_063125724.1

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394358.2 → NP_001381287.1 diacylglycerol kinase epsilon isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A096UWG9

Related

ENSRNOP00000003179.4, ENSRNOT00000003179.7

Conserved Domains (4) summary

smart00045
Location:367 → 524

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:219 → 347

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd20801
Location:55 → 108

C1_DGKepsilon_typeIII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins

cd20853
Location:123 → 187

C1_DGKepsilon_typeIII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins
NM_001394359.2 → NP_001381288.1 diacylglycerol kinase epsilon isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

Related

ENSRNOP00000100575.1, ENSRNOT00000142774.1

Conserved Domains (4) summary

smart00046
Location:219 → 347

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd20801
Location:55 → 108

C1_DGKepsilon_typeIII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins

cd20853
Location:123 → 187

C1_DGKepsilon_typeIII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins

cl02440
Location:367 → 500

DAGK_acc; Diacylglycerol kinase accessory domain