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    Vwa8 von Willebrand factor A domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290381, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vwa8provided by RGD
    Official Full Name
    von Willebrand factor A domain containing 8provided by RGD
    Primary source
    RGD:1308772
    See related
    EnsemblRapid:ENSRNOG00000053145 AllianceGenome:RGD:1308772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308772
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be located in mitochondrion and peroxisome. Orthologous to human VWA8 (von Willebrand factor A domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 326.9), Liver (RPKM 230.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vwa8 in Genome Data Viewer
    Location:
    15q11-q12
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (60661764..60985971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54252703..54576871)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61069439..61153292) , (61158510..61467462)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, eta Neighboring gene uncharacterized LOC108353040 Neighboring gene uncharacterized LOC120097120 Neighboring gene uncharacterized LOC120097121 Neighboring gene histidyl-tRNA synthetase 1, pseudogene 1 Neighboring gene uncharacterized LOC134482158 Neighboring gene glutamate-ammonia ligase, pseudogene 1 Neighboring gene regulator of cell cycle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Von Willebrand factor A domain-containing protein 8 (VWA8) localizes to the matrix side of the inner mitochondrial membrane. Luo M, et al. Biochem Biophys Res Commun, 2020 Jan 1. PMID 31630795, Free PMC Article
    2. Characterization of the novel protein KIAA0564 (Von Willebrand Domain-containing Protein 8). Luo M, et al. Biochem Biophys Res Commun, 2017 Jun 3. PMID 28414126, Free PMC Article
    3. A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein. Niwa H, et al. J Biochem, 2018 Dec 1. PMID 30204880
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The vMTS is essential for localization to the mitochondrial matrix and that once there, VWA8 localizes to the matrix side of inner mitochondrial membrane.
      Title: Von Willebrand factor A domain-containing protein 8 (VWA8) localizes to the matrix side of the inner mitochondrial membrane.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor A domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427283.1 → NP_001414212.1  von Willebrand factor A domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K3W1
      Related
      ENSRNOP00000072799.2, ENSRNOT00000084333.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      60661764..60985971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274157.1 → XP_063130227.1  von Willebrand factor A domain-containing protein 8 isoform X1

      Related
      ENSRNOP00000104923.1, ENSRNOT00000170597.1

    2. XM_039094044.2 → XP_038949972.1  von Willebrand factor A domain-containing protein 8 isoform X2

      Conserved Domains (3) summary
      COG5271
      Location:68 → 750
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam07728
      Location:9 → 165
      AAA_5; AAA domain (dynein-related subfamily)
      cl00057
      Location:1618 → 1807
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_039094045.2 → XP_038949973.1  von Willebrand factor A domain-containing protein 8 isoform X3

      Conserved Domains (2) summary
      pfam07728
      Location:112 → 259
      AAA_5; AAA domain (dynein-related subfamily)
      cl00057
      Location:1050 → 1239
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_063274158.1 → XP_063130228.1  von Willebrand factor A domain-containing protein 8 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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