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    Npy5r neuropeptide Y receptor Y5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25340, updated on 4-Jan-2025

    Summary

    Official Symbol
    Npy5rprovided by RGD
    Official Full Name
    neuropeptide Y receptor Y5provided by RGD
    Primary source
    RGD:3199
    See related
    EnsemblRapid:ENSRNOG00000014172 AllianceGenome:RGD:3199
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NPYR5
    Summary
    Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including generation of ovulation cycle rhythm; negative regulation of GABAergic synaptic transmission; and regulation of acute inflammatory response. Predicted to be located in membrane. Predicted to be active in several cellular components, including GABA-ergic synapse; neuron projection; and presynapse. Used to study childhood absence epilepsy; hyperinsulinism; and visual epilepsy. Biomarker of coronary restenosis; obesity; and prolactinoma. Human ortholog(s) of this gene implicated in lipid metabolism disorder and obesity. Orthologous to human NPY5R (neuropeptide Y receptor Y5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 14.9) See more
    Orthologs
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    Genomic context

    See Npy5r in Genome Data Viewer
    Location:
    16p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (27822055..27830012)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (23055427..23063384)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (24796685..24805730)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482367 Neighboring gene nuclear assembly factor 1 ribonucleoprotein Neighboring gene neuropeptide Y receptor Y1 Neighboring gene U7 small nuclear RNA Neighboring gene arginine/serine-rich protein PNISR-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables neuropeptide Y receptor activity PubMed 
    enables neuropeptide Y receptor activity  
    enables neuropeptide binding  
    enables pancreatic polypeptide receptor activity  
    enables pancreatic polypeptide receptor activity PubMed 
    enables pancreatic polypeptide receptor activity  
    enables peptide YY receptor activity  
    enables peptide YY receptor activity PubMed 
    enables peptide YY receptor activity  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in cardiac left ventricle morphogenesis  
    involved_in chemical synaptic transmission  
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in eating behavior PubMed 
    involved_in generation of ovulation cycle rhythm PubMed 
    involved_in negative regulation of acute inflammatory response to antigenic stimulus PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of glutamate secretion PubMed 
    involved_in negative regulation of synaptic transmission, GABAergic PubMed 
    involved_in neuropeptide signaling pathway  
    involved_in outflow tract morphogenesis  
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of acute inflammatory response PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of smooth muscle cell proliferation PubMed 
    involved_in synaptic signaling via neuropeptide  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in membrane  
    is_active_in neuron projection  
    located_in neuron projection  
    is_active_in plasma membrane  
    is_active_in presynapse  

    General protein information

    Preferred Names
    neuropeptide Y receptor type 5
    Names
    NPY-Y5 receptor
    NPY5-R
    NPYY5-R
    Neuropeptide Y5 receptor
    Y5 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012869.2NP_037001.1  neuropeptide Y receptor type 5

      See identical proteins and their annotated locations for NP_037001.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P70586, Q63634
      UniProtKB/TrEMBL
      A6KFL9
      Related
      ENSRNOP00000089710.1, ENSRNOT00000099301.2
      Conserved Domains (2) summary
      pfam00001
      Location:58424
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52170
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      27822055..27830012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253014.5XP_006253076.1  neuropeptide Y receptor type 5 isoform X1

      See identical proteins and their annotated locations for XP_006253076.1

      UniProtKB/Swiss-Prot
      P70586, Q63634
      UniProtKB/TrEMBL
      A6KFL9
      Related
      ENSRNOP00000103833.1, ENSRNOT00000124963.1
      Conserved Domains (2) summary
      pfam00001
      Location:58424
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52170
      7tm_4; Olfactory receptor
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