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    Ppm1h protein phosphatase, Mg2+/Mn2+ dependent, 1H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314897, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppm1hprovided by RGD
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent, 1Hprovided by RGD
    Primary source
    RGD:1309528
    See related
    EnsemblRapid:ENSRNOG00000004314 AllianceGenome:RGD:1309528
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and identical protein binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in glutamatergic synapse and mitochondrion. Orthologous to human PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 148.9), Brain (RPKM 106.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppm1h in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (60224087..60484947)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (58338661..58599547)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (66845692..67116979, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 1A Neighboring gene uncharacterized LOC134479598 Neighboring gene uncharacterized LOC134479882 Neighboring gene uncharacterized LOC134479883 Neighboring gene nascent polypeptide-associated complex subunit alpha, muscle-specific form-like Neighboring gene microRNA let-7i Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene SNRPN upstream open reading frame like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables identical protein binding  
    enables myosin phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    Process Evidence Code Pubs
    involved_in chromatin remodeling  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in glutamatergic synapse  
    is_active_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    is_active_in synapse  

    General protein information

    Preferred Names
    protein phosphatase 1H
    Names
    protein phosphatase 1H (PP2C domain containing)
    NP_001258008.1
    XP_038935073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271079.2NP_001258008.1  protein phosphatase 1H

      See identical proteins and their annotated locations for NP_001258008.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5M821
      Related
      ENSRNOP00000005798.4, ENSRNOT00000005798.9
      Conserved Domains (1) summary
      cd00143
      Location:142506
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      60224087..60484947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079145.2XP_038935073.1  protein phosphatase 1H isoform X1

      Conserved Domains (1) summary
      cl00120
      Location:142312
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

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