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    Rfwd3 ring finger and WD repeat domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 103690025, updated on 9-Dec-2024

    Summary

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    Symbol
    Rfwd3provided by RGD
    Full Name
    ring finger and WD repeat domain 3provided by RGD
    Primary source
    RGD:1305243
    See related
    EnsemblRapid:ENSRNOG00000051461 AllianceGenome:RGD:1305243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305243
    Summary
    Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Predicted to be located in nucleoplasm and site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group W. Orthologous to human RFWD3 (ring finger and WD repeat domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 85.3), Spleen (RPKM 77.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rfwd3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56145221..56177871, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39235883..39268479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43477121..43499068, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene essential MCU regulator, mitochondrial-like Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene golgi glycoprotein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene mixed lineage kinase domain like pseudokinase Neighboring gene fatty acid 2-hydroxylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia. Knies K, et al. J Clin Invest, 2017 Aug 1. PMID 28691929, Free PMC Article
    2. RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health. Feeney L, et al. Mol Cell, 2017 Jun 1. PMID 28575657, Free PMC Article
    3. RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage. Fu X, et al. Proc Natl Acad Sci U S A, 2010 Mar 9. PMID 20173098, Free PMC Article
    4. RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination. Inano S, et al. Mol Cell, 2017 Jun 1. PMID 28575658
    5. E3 ligase RFWD3 participates in replication checkpoint control. Gong Z, et al. J Biol Chem, 2011 Jun 24. PMID 21504906, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RFWD3
    Names
    E3 ubiquitin-protein ligase RFWD3-like
    NP_001389130.1
    NP_001389131.1
    XP_063133796.1
    XP_063133797.1
    XP_063133798.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402201.1 → NP_001389130.1  E3 ubiquitin-protein ligase RFWD3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IZ86

    2. NM_001402202.1 → NP_001389131.1  E3 ubiquitin-protein ligase RFWD3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6A1A6, A6IZ86
      Related
      ENSRNOP00000084997.1, ENSRNOT00000078854.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56145221..56177871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277727.1 → XP_063133797.1  E3 ubiquitin-protein ligase RFWD3 isoform X2

    2. XM_063277726.1 → XP_063133796.1  E3 ubiquitin-protein ligase RFWD3 isoform X1

    3. XM_063277728.1 → XP_063133798.1  E3 ubiquitin-protein ligase RFWD3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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