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    Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291057, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eef1e1provided by RGD
    Official Full Name
    eukaryotic translation elongation factor 1 epsilon 1provided by RGD
    Primary source
    RGD:1311056
    See related
    EnsemblRapid:ENSRNOG00000066344 AllianceGenome:RGD:1311056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of cell population proliferation; positive regulation of apoptotic process; and positive regulation of cellular senescence. Predicted to act upstream of or within cellular response to leukemia inhibitory factor; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic signaling pathway. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 251.4), Brain (RPKM 203.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eef1e1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (26354247..26364953)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (26148652..26159358)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (26785017..26795723)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097954 Neighboring gene solute carrier family 35 member B3 Neighboring gene DNA polymerase epsilon 3, accessory subunit, pseudogene 2 Neighboring gene uncharacterized LOC134482843 Neighboring gene putative protein CRIPAK Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex  
    part_of aminoacyl-tRNA synthetase multienzyme complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    eukaryotic translation elongation factor 1 epsilon-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106106.1NP_001099576.1  eukaryotic translation elongation factor 1 epsilon-1

      See identical proteins and their annotated locations for NP_001099576.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473977
      UniProtKB/TrEMBL
      A0A8I6AE61, B2RYN3
      Related
      ENSRNOP00000105610.1, ENSRNOT00000142300.1
      Conserved Domains (1) summary
      cd10305
      Location:65165
      GST_C_AIMP3; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      26354247..26364953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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