Paox polyamine oxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Paoxprovided by RGD
Official Full Name: polyamine oxidaseprovided by RGD
Primary source: RGD:1561125
See related: EnsemblRapid:ENSRNOG00000018838 AllianceGenome:RGD:1561125
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables polyamine oxidase activity. Involved in putrescine catabolic process; spermidine catabolic process; and spermine catabolic process. Located in peroxisomal matrix. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 118.7), Kidney (RPKM 82.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (204349326..204358140)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (194919655..194928498)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (212578444..212603722)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amine oxidases are important mediators of pathological processes of rhabdomyolysis in rats.
Title: Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

Paox (e-PCR), detects polymorphism
- UniSTS:531482

RH141911 (e-PCR)
- UniSTS:223902

AI118225 (e-PCR)
- UniSTS:163246

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables polyamine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polyamine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables polyamine oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in polyamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within polyamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in polyamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of spermidine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in putrescine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in putrescine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in putrescine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in spermidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermidine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in spermine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in spermine catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Names: GTP-binding protein-like; polyamine oxidase (exo-N4-amino); putative GTP-binding protein

NP_001385701.1

EC 1.5.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398772.1 → NP_001385701.1 peroxisomal N(1)-acetyl-spermine/spermidine oxidase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AEP5, A6HXG9, A6HXH1, D3Z8W0

Related

ENSRNOP00000091101.2, ENSRNOT00000098933.2

Conserved Domains (1) summary

PLN02568
Location:1 → 489

PLN02568; polyamine oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

204349326..204358140

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106311.1: Suppressed sequence

Description

NM_001106311.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.