Pex16 peroxisomal biogenesis factor 16 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pex16provided by RGD
Official Full Name: peroxisomal biogenesis factor 16provided by RGD
Primary source: RGD:1311372
See related: EnsemblRapid:ENSRNOG00000006539 AllianceGenome:RGD:1311372
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in peroxisome organization and protein to membrane docking. Predicted to act upstream of or within protein import into peroxisome matrix. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in Peroxisome biogenesis disorder 8B and peroxisome biogenesis disorder 8A. Orthologous to human PEX16 (peroxisomal biogenesis factor 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 233.2), Liver (RPKM 197.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (98800357..98808091)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (78347212..78352603)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (81283137..81292575)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI171187 (e-PCR)
- UniSTS:250453

BE100549 (e-PCR)
- UniSTS:249827

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome localization	ISO Inferred from Sequence Orthology more info
involved_in ER-dependent peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in peroxisome membrane biogenesis	ISO Inferred from Sequence Orthology more info
involved_in peroxisome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into peroxisome matrix	ISO Inferred from Sequence Orthology more info
involved_in protein import into peroxisome membrane	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to peroxisome	ISO Inferred from Sequence Orthology more info
involved_in protein to membrane docking	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal biogenesis factor 16

Names: peroxisome biogenesis factor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012088.2 → NP_001012088.2 peroxisomal biogenesis factor 16

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2JV14, A0A0G2JWT6, A6HNG5

Related

ENSRNOP00000070009.1, ENSRNOT00000086530.3

Conserved Domains (1) summary

pfam08610
Location:10 → 329

Pex16; Peroxisomal membrane protein (Pex16)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

98800357..98808091

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283672.1 → XP_063139742.1 peroxisomal biogenesis factor 16 isoform X1

UniProtKB/TrEMBL

A0A0G2JV14
XM_063283674.1 → XP_063139744.1 peroxisomal biogenesis factor 16 isoform X3
XM_039104907.2 → XP_038960835.1 peroxisomal biogenesis factor 16 isoform X4

Conserved Domains (1) summary

pfam08610
Location:10 → 181

Pex16; Peroxisomal membrane protein (Pex16)
XM_063283673.1 → XP_063139743.1 peroxisomal biogenesis factor 16 isoform X2

UniProtKB/TrEMBL

A6HNG6