Cst5 cystatin D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cst5provided by RGD
Official Full Name: cystatin Dprovided by RGD
Primary source: RGD:1310978
See related: EnsemblRapid:ENSRNOG00000005545 AllianceGenome:RGD:1310978
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cst10
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including bone mineralization; calcium ion homeostasis; and endochondral bone morphogenesis. Predicted to act upstream of or within cell maturation and chondrocyte differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in cytoplasm; extracellular space; and vesicle. Orthologous to several human genes including CST5 (cystatin D). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 3q41

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (158033791..158038345)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (137573194..137577754)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (144569502..144574112)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Up-regulated CST5 inhibits bone resorption and activation of osteoclasts in rat models of osteoporosis via suppression of the NF-kappaB pathway.
Title: Up-regulated CST5 inhibits bone resorption and activation of osteoclasts in rat models of osteoporosis via suppression of the NF-κB pathway.
a function for cystatin D in the regulation of antigen-presenting cell activity
Title: Antigen-presenting cells in parotid glands contain cystatin D originating from acinar cells.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage chondrocyte growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cystatin-D

Names: cystatin 10 (chondrocytes)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.