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    Rpap3 RNA polymerase II associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 71919, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rpap3provided by MGI
    Official Full Name
    RNA polymerase II associated protein 3provided by MGI
    Primary source
    MGI:MGI:1277218
    See related
    Ensembl:ENSMUSG00000022466 AllianceGenome:MGI:1277218
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15Ertd682e; 2310042P20Rik
    Summary
    Predicted to be located in cytosol. Predicted to be part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and protein folding chaperone complex. Orthologous to human RPAP3 (RNA polymerase II associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.3), CNS E18 (RPKM 8.9) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpap3 in Genome Data Viewer
    Location:
    15 F1; 15 53.54 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97572978..97603746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97675097..97705822, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39629 Neighboring gene predicted gene, 41393 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97289192-97289405 Neighboring gene STARR-seq mESC enhancer starr_39631 Neighboring gene STARR-seq mESC enhancer starr_39632 Neighboring gene STARR-seq mESC enhancer starr_39633 Neighboring gene STARR-seq mESC enhancer starr_39634 Neighboring gene predicted gene, 41394 Neighboring gene STARR-positive B cell enhancer ABC_E10876 Neighboring gene STARR-positive B cell enhancer ABC_E7415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97551732-97551973 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97561501-97561858 Neighboring gene STARR-positive B cell enhancer ABC_E5512 Neighboring gene STARR-positive B cell enhancer ABC_E2450 Neighboring gene endonuclease, polyU-specific Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene predicted gene, 33531

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Maurizy C, et al. Nat Commun, 2021 Aug 10. PMID 34376666, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of R2TP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of R2TP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RPAP3/R2TP/prefoldin-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028003.2 → NP_082279.1  RNA polymerase II-associated protein 3

      See identical proteins and their annotated locations for NP_082279.1

      Status: PROVISIONAL

      Source sequence(s)
      AK009765
      Consensus CDS
      CCDS27782.1
      UniProtKB/Swiss-Prot
      Q9D706
      Related
      ENSMUSP00000023104.6, ENSMUST00000023104.7
      Conserved Domains (4) summary
      PLN03088
      Location:137 → 257
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      TIGR00990
      Location:112 → 385
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:134 → 162
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:540 → 627
      RPAP3_C; Potential Monad-binding region of RPAP3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97572978..97603746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159597.1 → XP_036015490.1  RNA polymerase II-associated protein 3 isoform X1

      Conserved Domains (4) summary
      PLN03088
      Location:137 → 257
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      TIGR00990
      Location:112 → 385
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:134 → 162
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:540 → 616
      RPAP3_C; Potential Monad-binding region of RPAP3

    2. XM_011245735.2 → XP_011244037.1  RNA polymerase II-associated protein 3 isoform X2

      Conserved Domains (3) summary
      PLN03088
      Location:135 → 270
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:124 → 152
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:380 → 467
      RPAP3_C; Potential Monad-binding region of RPAP3

    3. XM_036159598.1 → XP_036015491.1  RNA polymerase II-associated protein 3 isoform X3

      Conserved Domains (3) summary
      PLN03088
      Location:2 → 105
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:26 → 56
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:215 → 302
      RPAP3_C; Potential Monad-binding region of RPAP3

    4. XM_030248782.2 → XP_030104642.1  RNA polymerase II-associated protein 3 isoform X3

      Conserved Domains (3) summary
      PLN03088
      Location:2 → 105
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:26 → 56
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:215 → 302
      RPAP3_C; Potential Monad-binding region of RPAP3

    5. XM_030248783.1 → XP_030104643.1  RNA polymerase II-associated protein 3 isoform X3

      Conserved Domains (3) summary
      PLN03088
      Location:2 → 105
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      sd00006
      Location:26 → 56
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:215 → 302
      RPAP3_C; Potential Monad-binding region of RPAP3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D706.1 GenPept UniProtKB/Swiss-Prot:Q9D706

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