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    C2 complement C2 [ Mus musculus (house mouse) ]

    Gene ID: 12263, updated on 9-Dec-2024

    Summary

    Official Symbol
    C2provided by MGI
    Official Full Name
    complement C2provided by MGI
    Primary source
    MGI:MGI:88226
    See related
    Ensembl:ENSMUSG00000024371 AllianceGenome:MGI:88226
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]
    Expression
    Broad expression in adrenal adult (RPKM 31.9), liver adult (RPKM 28.9) and 19 other tissues See more
    Orthologs
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    Genomic context

    Location:
    17 B1; 17 18.41 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35081578..35101076, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34862602..34882100, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member E, Rdbp Neighboring gene microRNA 6972 Neighboring gene complement factor B Neighboring gene STARR-seq mESC enhancer starr_42440 Neighboring gene predicted gene, 40706 Neighboring gene zinc finger and BTB domain containing 12 Neighboring gene euchromatic histone lysine N-methyltransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to thyroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

    Preferred Names
    complement C2
    Names
    MHC complement component C2
    classical-complement pathway C3/C5 convertase
    complement component 2 (within H-2S)
    complement component C2
    complement factor C2
    NP_038512.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013484.3NP_038512.2  complement C2 preproprotein

      See identical proteins and their annotated locations for NP_038512.2

      Status: REVIEWED

      Source sequence(s)
      CT025759, CT573030
      Consensus CDS
      CCDS28664.1
      UniProtKB/Swiss-Prot
      O70350, P21180
      UniProtKB/TrEMBL
      B8JJN2
      Related
      ENSMUSP00000025230.9, ENSMUST00000025230.15
      Conserved Domains (5) summary
      cd00033
      Location:94149
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:480721
      Tryp_SPc; Trypsin-like serine protease
      smart00032
      Location:156210
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      cd00190
      Location:480750
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cl00057
      Location:260457
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35081578..35101076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)