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    Fbxo7 F-box protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 69754, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxo7provided by MGI
    Official Full Name
    F-box protein 7provided by MGI
    Primary source
    MGI:MGI:1917004
    See related
    Ensembl:ENSMUSG00000001786 AllianceGenome:MGI:1917004
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410015K21Rik; A230052G17Rik
    Summary
    Enables protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and negative regulation of lymphocyte differentiation. Located in mitochondrion and nucleus. Is expressed in dorsal root ganglion; gallbladder; liver; trigeminal ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 26.7), liver E14.5 (RPKM 23.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxo7 in Genome Data Viewer
    Location:
    10 C1; 10 41.91 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (85856313..85887737)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86020449..86051873)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11450 Neighboring gene predicted gene, 48175 Neighboring gene RNA 2',3'-cyclic phosphate and 5'-OH ligase Neighboring gene BPI fold containing family C Neighboring gene STARR-seq mESC enhancer starr_27455 Neighboring gene STARR-positive B cell enhancer ABC_E8355 Neighboring gene predicted gene, 24430 Neighboring gene RIKEN cDNA 4930486F22 gene Neighboring gene STARR-seq mESC enhancer starr_27456 Neighboring gene predicted gene, 51812 Neighboring gene synapsin III

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of lymphocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of lymphocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Lewy body core IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Lewy body core ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Lewy body corona IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Lewy body corona ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Lewy neurite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Lewy neurite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in classical Lewy body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in classical Lewy body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in glial cytoplasmic inclusion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glial cytoplasmic inclusion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310745.1NP_001297674.1  F-box only protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001297674.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC122919, AK010499, AK150190
      Consensus CDS
      CCDS78875.1
      UniProtKB/TrEMBL
      Q3UD93
      Related
      ENSMUSP00000113222.2, ENSMUST00000120344.8
      Conserved Domains (3) summary
      pfam06881
      Location:293335
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:110243
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:257300
      F-box-like; F-box-like
    2. NM_001347151.1NP_001334080.1  F-box only protein 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122919, AI447461, AK082146, AK147716, AK147907, AK150626
      Consensus CDS
      CCDS83740.1
      UniProtKB/TrEMBL
      Q3UGI9
      Related
      ENSMUSP00000113263.2, ENSMUST00000117597.2
      Conserved Domains (3) summary
      pfam06881
      Location:291333
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:112237
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:255296
      F-box-like
    3. NM_153195.2NP_694875.2  F-box only protein 7 isoform 1

      See identical proteins and their annotated locations for NP_694875.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK151025, CD563204
      Consensus CDS
      CCDS24095.1
      UniProtKB/Swiss-Prot
      Q3U7U3, Q3UBC1, Q8K0A5
      Related
      ENSMUSP00000120840.2, ENSMUST00000130320.8
      Conserved Domains (3) summary
      pfam06881
      Location:372414
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:189322
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:336379
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      85856313..85887737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314077.2XP_017169566.1  F-box only protein 7 isoform X1

      Conserved Domains (4) summary
      pfam06881
      Location:340382
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:193292
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:304345
      F-box-like
      cl28922
      Location:177
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_011243556.3XP_011241858.1  F-box only protein 7 isoform X2

      See identical proteins and their annotated locations for XP_011241858.1

      Conserved Domains (3) summary
      pfam06881
      Location:234276
      Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
      pfam11566
      Location:55180
      PI31_Prot_N; PI31 proteasome regulator N-terminal
      pfam12937
      Location:198239
      F-box-like