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    Enkur enkurin, TRPC channel interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 71233, updated on 27-Nov-2024

    Summary

    Official Symbol
    Enkurprovided by MGI
    Official Full Name
    enkurin, TRPC channel interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1918483
    See related
    Ensembl:ENSMUSG00000026679 AllianceGenome:MGI:1918483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933434I06Rik
    Summary
    Enables calmodulin binding activity. Involved in flagellated sperm motility. Acts upstream of or within establishment of left/right asymmetry. Located in 9+0 motile cilium; acrosomal vesicle; and sperm principal piece. Is active in axonemal B tubule inner sheath. Is expressed in lung; node; testis; and trachea. Orthologous to human ENKUR (enkurin, TRPC channel interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 14.0), CNS E18 (RPKM 1.9) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Enkur in Genome Data Viewer
    Location:
    2 A3; 2 14.82 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (21185542..21210176, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (21180731..21205365, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 21 Neighboring gene STARR-positive B cell enhancer ABC_E5897 Neighboring gene STARR-seq mESC enhancer starr_03884 Neighboring gene STARR-seq mESC enhancer starr_03887 Neighboring gene predicted gene 13375 Neighboring gene VISTA enhancer mm1447 Neighboring gene phosphoribosyltransferase domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03890 Neighboring gene STARR-seq mESC enhancer starr_03891 Neighboring gene STARR-positive B cell enhancer ABC_E1240 Neighboring gene STARR-seq mESC enhancer starr_03892 Neighboring gene threonine synthase-like 1 (bacterial) Neighboring gene PHD finger protein 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117794

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in 9+0 motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in 9+2 motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axonemal B tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axonemal microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in sperm flagellum EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm principal piece IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027728.2NP_082004.1  enkurin

      See identical proteins and their annotated locations for NP_082004.1

      Status: VALIDATED

      Source sequence(s)
      AK017056, BC099519
      Consensus CDS
      CCDS38055.1
      UniProtKB/Swiss-Prot
      Q6SP97
      UniProtKB/TrEMBL
      Q4KL11
      Related
      ENSMUSP00000027992.3, ENSMUST00000027992.3
      Conserved Domains (1) summary
      pfam13864
      Location:152246
      Enkurin; Calmodulin-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      21185542..21210176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)